|
gptkbp:instanceOf
|
gptkb:antibiotic
carbapenem
|
|
gptkbp:administrationFrequency
|
every 8 hours
|
|
gptkbp:approvalYear
|
1996
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:ATCCode
|
J01DH02
|
|
gptkbp:brand
|
gptkb:Merrem
gptkb:Meronem
|
|
gptkbp:CASNumber
|
96036-03-2
|
|
gptkbp:chemicalFormula
|
C17H25N3O5S
|
|
gptkbp:contraindication
|
hypersensitivity to carbapenems
|
|
gptkbp:discoveredBy
|
gptkb:Sumitomo_Pharmaceuticals
|
|
gptkbp:drugClass
|
gptkb:antibiotic
|
|
gptkbp:effect
|
Gram-negative bacteria
Gram-positive bacteria
anaerobic bacteria
|
|
gptkbp:eliminationHalfLife
|
1 hour
|
|
gptkbp:excretion
|
renal
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
meropenem
|
|
gptkbp:indication
|
gptkb:pneumonia
bacterial meningitis
complicated intra-abdominal infections
complicated skin and soft tissue infections
|
|
gptkbp:interactsWith
|
gptkb:valproic_acid
gptkb:probenecid
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
inhibits cell wall synthesis
|
|
gptkbp:MedlinePlusID
|
a601206
|
|
gptkbp:metabolism
|
not significantly metabolized
|
|
gptkbp:molecularWeight
|
383.46 g/mol
|
|
gptkbp:notEffectiveAgainst
|
gptkb:methicillin-resistant_Staphylococcus_aureus
gptkb:Enterococcus_faecium
|
|
gptkbp:origin
|
synthetic
|
|
gptkbp:pregnancyCategory
|
gptkb:B2
B (US)
|
|
gptkbp:proteinBinding
|
~2%
|
|
gptkbp:PubChem_CID
|
441130
CHEMBL1173
|
|
gptkbp:riskFactor
|
gptkb:Clostridioides_difficile_infection
|
|
gptkbp:routeOfAdministration
|
intravenous
|
|
gptkbp:sideEffect
|
nausea
diarrhea
seizures
rash
|
|
gptkbp:solubility
|
water soluble
|
|
gptkbp:spectrumOfActivity
|
broad-spectrum
|
|
gptkbp:storage
|
below 25°C
|
|
gptkbp:UNII
|
7U0O4M6X9E
|
|
gptkbp:usedFor
|
bacterial infections
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
included
|
|
gptkbp:bfsParent
|
gptkb:Carbavance
gptkb:Vabomere
|
|
gptkbp:bfsLayer
|
6
|