Statements (272)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:DNA
gptkb:Biology |
| gptkbp:alias |
CYP26, CYP26 A, CYP26 A1 gene
|
| gptkbp:application |
cancer studies
retinoid metabolism studies on congenital disorders involved in retinoid homeostasis |
| gptkbp:associated_phenotypes |
abnormal limb development
|
| gptkbp:associated_with |
gptkb:diabetes
fertility environmental factors reproductive health aging apoptosis cell cycle regulation cell differentiation developmental processes immune response metabolic disorders nutritional status transcription factors autoimmune diseases chronic diseases cognitive function inflammation metabolic syndrome obesity wound healing stem cell biology cardiovascular diseases cell signaling pathways oxidative stress response synaptic plasticity tissue regeneration cancer progression neurogenesis developmental disorders gene expression regulation epigenetic modifications neuroprotection hormonal regulation neurotransmitter regulation neurodevelopmental disorders skin disorders lifestyle diseases immune system regulation endocrine function cardiometabolic health chromatin remodeling. retinoic acid signaling dietary influences |
| gptkbp:biological_assays |
used in pharmacological studies
|
| gptkbp:biological_importance |
critical for embryonic development
|
| gptkbp:breeding_range |
chromosome 19
|
| gptkbp:catalytic_activity |
catalyzes hydroxylation reactions
|
| gptkbp:cellular_functions |
influences cell differentiation
|
| gptkbp:challenges |
embryonic malformations
causes craniofacial abnormalities |
| gptkbp:clinical_implications |
impact on drug metabolism
|
| gptkbp:clinical_relevance |
implicated in teratogenic effects
|
| gptkbp:clinical_trial |
potential drug target
target for drug development associated with congenital disorders focus on retinoid signaling. studies involving retinoic acid potential target for cancer therapy |
| gptkbp:code |
gptkb:cytochrome_P450_26_A1_protein
|
| gptkbp:collaborations |
international research groups
|
| gptkbp:conservation |
highly conserved across species
|
| gptkbp:diseases |
neurodevelopmental disorders
retinoic acid-related disorders associated with congenital malformations |
| gptkbp:disrupted_in |
certain cancers
|
| gptkbp:ecological_role |
metabolizing retinoids
|
| gptkbp:enzyme_classification |
gptkb:EC_1.14.13.82
|
| gptkbp:enzyme_type |
monooxygenase
|
| gptkbp:expression_analysis |
quantitative PCR studies
using q PCR |
| gptkbp:expression_in |
adult tissues
|
| gptkbp:expression_in_cancer |
varied across cancer types
|
| gptkbp:expression_in_embryos |
is critical for development
|
| gptkbp:family |
part of the cytochrome P450 family
|
| gptkbp:function |
catalyzes oxidation reactions
metabolizes retinoic acid |
| gptkbp:functional_assays |
enzyme activity tests
substrate specificity tests to assess enzyme activity |
| gptkbp:functional_characterization |
enzyme kinetics studies
|
| gptkbp:functional_domains |
catalytic domain
|
| gptkbp:functional_studies |
investigated in model organisms
analyze enzyme activity |
| gptkbp:fuselage_material |
9-cis-retinoic acid
all-trans-retinoic acid retinoic acid metabolites |
| gptkbp:gene_expression |
regulated by retinoic acid levels
|
| gptkbp:gene_expression_patterns |
varies during development
|
| gptkbp:gene_expression_regulation |
retinoic acid levels
|
| gptkbp:gene_interactions |
with other metabolic genes
|
| gptkbp:gene_mapping |
mapped to 10q24.1
|
| gptkbp:genetic_disorders |
linked to specific syndromes
|
| gptkbp:genetic_diversity |
single nucleotide polymorphisms
can influence phenotypic traits |
| gptkbp:genetic_studies |
congenital disorders
conserved across vertebrates mutations can lead to developmental disorders link to phenotypic traits retinoic acid signaling disruption affect embryonic development |
| gptkbp:genomic_context |
surrounding genes on chromosome 10
|
| gptkbp:has_function |
gptkb:CYP26
hydroxylation of retinoic acid oxidation of retinoic acid |
| gptkbp:has_related_gene |
gptkb:CYP26_B1
gptkb:CYP26_C1 |
| gptkbp:has_role |
gptkb:embryonic_development
cell differentiation |
| gptkbp:has_variants |
CYP26 A1 polymorphisms
|
| https://www.w3.org/2000/01/rdf-schema#label |
CYP26 A1
|
| gptkbp:influences |
cell fate decisions
|
| gptkbp:initiated_by |
chemical compounds affecting activity
retinoic acid signaling can affect its activity R115866 CYP26 A1 inhibitors |
| gptkbp:interacts_with |
retinoic acid
interacts with other cytochrome P450 enzymes |
| gptkbp:involved_in |
gptkb:embryonic_development
neurogenesis retinoic acid metabolism retinoic acid homeostasis |
| gptkbp:involvement |
neural patterning
|
| gptkbp:is_a_tool_for |
antibodies and assays
|
| gptkbp:is_associated_with |
gptkb:diabetes
gptkb:neurodegenerative_diseases metabolic disorders metabolic syndrome cancer research cardiovascular diseases aging process birth defects neurodevelopmental disorders |
| gptkbp:is_expressed_in |
gptkb:Brain
gptkb:Skin human liver kidney liver muscle tissue placenta embryogenesis embryonic tissues adult tissues neural tissues varies during development high in fetal tissues low in adult tissues |
| gptkbp:is_involved_in |
apoptosis
cell cycle regulation cell differentiation cell proliferation cell signaling cellular stress response immune response metabolic pathways metabolic processes signal transduction wound healing cell signaling pathways cellular differentiation eye development neurogenesis organogenesis gene expression regulation hormonal regulation stem cell maintenance cellular signaling vascular development tissue homeostasis heart development limb development retinoid signaling pathway retinoic acid-induced differentiation of stem cells cellular response to retinoic acid retinoic acid-induced apoptosis retinoic acid-induced apoptosis in cancer cells retinoic acid-induced cell cycle arrest retinoic acid-induced cell death retinoic acid-induced differentiation retinoic acid-induced gene expression retinoic acid-induced neurogenesis retinoic acid-induced signaling |
| gptkbp:is_linked_to |
obesity
chronic inflammation infertility issues autism spectrum disorders congenital malformations |
| gptkbp:is_part_of |
retinoid signaling pathway
|
| gptkbp:is_regulated_by |
transcription factors
retinoic acid |
| gptkbp:is_studied_for |
therapeutic interventions
regenerative medicine cancer therapies its role in cancer biology gene therapy applications |
| gptkbp:is_studied_in |
gptkb:Genetics
molecular biology toxicology pharmacology pharmacogenomics developmental biology mouse models toxicology research |
| gptkbp:is_targeted_at |
retinoic acid derivatives
|
| gptkbp:knockdown_effects |
affect cell differentiation
|
| gptkbp:knockout_studies |
animal models
used to study gene function |
| gptkbp:located_in |
human chromosome 10
mouse genome rat genome |
| gptkbp:location |
liver
|
| gptkbp:molecular_mechanism |
regulates gene expression
|
| gptkbp:notable_work |
highlight its importance in development.
|
| gptkbp:nutritional_value |
gptkb:cytochrome_P450_superfamily
predominantly in liver binding partners catalyzes oxidation reactions contains heme group hydroxylation of retinoids CYP26 A1 enzyme |
| gptkbp:orthologs |
found in other species
CYP26 A1 in other species CYP26 A1 in mice CYP26 A1 in rats CYP26 A1 in humans |
| gptkbp:part_of |
cytochrome P450 family 26
retinoid signaling pathway |
| gptkbp:pathological_role |
in cancer progression
|
| gptkbp:pathway |
involved in drug metabolism
retinoid metabolism pathway retinoic acid degradation retinoid metabolism |
| gptkbp:post_translational_modifications |
phosphorylation
|
| gptkbp:promoter |
gptkb:Cyp26a1
biological processes cytochrome P450 family cytochrome P450 family 26 CYP26 A1 gene |
| gptkbp:protein_variants |
alternative splicing forms
|
| gptkbp:publication |
numerous studies published
|
| gptkbp:regulates |
retinoic acid levels
retinoic acid signaling |
| gptkbp:regulatory_compliance |
by transcription factors
retinoic acid signaling regulated by retinoic acid levels |
| gptkbp:research |
CRISPR gene editing
studied in developmental biology studied in pharmacology studied in various contexts |
| gptkbp:research_areas |
modulating retinoic acid levels
|
| gptkbp:research_focus |
developmental biology
|
| gptkbp:research_institutes |
retinoic acid signaling pathways
|
| gptkbp:role |
in embryonic development
regulation of retinoic acid levels |
| gptkbp:seed_dispersal |
gptkb:Biology
protein-coding gene |
| gptkbp:subcellular_location |
endoplasmic reticulum
|
| gptkbp:targets |
gptkb:pharmaceuticals
pharmacological agents |
| gptkbp:transcription_factors |
regulatory proteins
|
| gptkbp:transcriptional_regulators |
influence its expression
|
| gptkbp:weight |
approximately 55 k Da
|
| gptkbp:bfsParent |
gptkb:Retinoic_acid_receptors
|
| gptkbp:bfsLayer |
6
|