Statements (59)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:DNA
|
| gptkbp:application |
gptkb:gene_therapy
developmental biology |
| gptkbp:associated_with |
developmental processes
craniofacial development neural tube defects retinoic acid signaling dysregulation teratogenic effects of retinoids |
| gptkbp:challenges |
embryonic malformations
|
| gptkbp:clinical_trial |
potential target for cancer therapy
|
| gptkbp:code |
gptkb:cytochrome_P450_26_A1_protein
|
| gptkbp:diseases |
birth defects
|
| gptkbp:ecological_role |
regulation of retinoic acid signaling
|
| gptkbp:expression_in |
adult tissues
neural crest cells |
| gptkbp:expression_levels |
varies during development
|
| gptkbp:expression_patterns |
dynamic during embryogenesis
|
| gptkbp:function |
catalyzes oxidation reactions
|
| gptkbp:functional_assays |
used to study enzyme activity
|
| gptkbp:functional_domains |
heme-binding domain
|
| gptkbp:genetic_studies |
highly conserved across species
linked to congenital disorders |
| gptkbp:genetic_variants |
affect gene function
|
| https://www.w3.org/2000/01/rdf-schema#label |
Cyp26a1
|
| gptkbp:influences |
cell differentiation
cell fate decisions other developmental genes retinoic acid signaling gradients |
| gptkbp:initiated_by |
retinoic acid
|
| gptkbp:interacts_with |
retinoic acid receptors
|
| gptkbp:involved_in |
limb development
retinoic acid metabolism |
| gptkbp:involvement |
neurogenesis
|
| gptkbp:is_expressed_in |
embryonic tissues
spatially restricted |
| gptkbp:is_linked_to |
embryonic patterning
|
| gptkbp:is_recognized_as |
zebrafish
|
| gptkbp:is_studied_for |
its role in cancer biology
its role in embryonic development |
| gptkbp:is_studied_in |
mouse models
various model organisms |
| gptkbp:knockout_studies |
demonstrated essential role in development
|
| gptkbp:located_in |
chromosome 19
|
| gptkbp:notable_work |
highlight its importance in development.
|
| gptkbp:nutritional_value |
metabolizes retinoic acid
|
| gptkbp:orthologs |
CYP26 A1 in humans
|
| gptkbp:part_of |
retinoic acid signaling pathway
|
| gptkbp:pathway |
metabolism of retinoids
|
| gptkbp:promoter |
gptkb:CYP26_A1
cytochrome P450 family |
| gptkbp:regulates |
retinoic acid levels
|
| gptkbp:regulatory_compliance |
influenced by environmental factors
|
| gptkbp:related_to |
CYP26 family of enzymes
|
| gptkbp:research |
gene knockout techniques
|
| gptkbp:research_focus |
retinoic acid signaling pathways
|
| gptkbp:seed_dispersal |
protein-coding gene
|
| gptkbp:transcriptional_regulation |
regulated by transcription factors
|
| gptkbp:bfsParent |
gptkb:CYP26_A1
|
| gptkbp:bfsLayer |
7
|