cytochrome P450 26 A1 protein
GPTKB entity
Statements (60)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:affects |
gene expression
|
| gptkbp:application |
retinoid metabolic process
studies on retinoic acid signaling |
| gptkbp:associated_with |
gptkb:neurodegenerative_diseases
cardiovascular diseases cancer progression neurodevelopmental disorders toxicity of retinoids |
| gptkbp:breeding_range |
chromosome 10
|
| gptkbp:cellular_component |
endoplasmic reticulum
|
| gptkbp:clinical_trial |
potential drug interactions
|
| gptkbp:diseases |
retinoic acid syndrome
|
| gptkbp:enzyme_classification |
EC 1.14.13.90
|
| gptkbp:enzyme_type |
monooxygenase
|
| gptkbp:family |
cytochrome P450 family 26
|
| gptkbp:fauna |
gptkb:Anthropology
|
| gptkbp:function |
metabolism of retinoic acid
|
| gptkbp:fuselage_material |
all-trans-retinoic acid
|
| https://www.w3.org/2000/01/rdf-schema#label |
cytochrome P450 26 A1 protein
|
| gptkbp:influences |
cell differentiation
cellular metabolism cellular stress response retinoid signaling pathways |
| gptkbp:inhibitory_effects |
retinoic acid levels
|
| gptkbp:initiated_by |
gptkb:ketoconazole
|
| gptkbp:interacts_with |
NADPH-cytochrome P450 reductase
|
| gptkbp:involved_in |
gptkb:embryonic_development
apoptosis regulation cell cycle regulation metabolic pathways cell signaling pathways xenobiotic metabolism hormonal regulation immune response modulation cellular detoxification |
| gptkbp:is_expressed_in |
embryonic tissues
developmental stages |
| gptkbp:is_linked_to |
metabolic disorders
developmental anomalies |
| gptkbp:is_studied_for |
therapeutic interventions
therapeutic targets biomarker potential |
| gptkbp:is_studied_in |
pharmacogenomics
|
| gptkbp:known_for |
retinoic acid degradation
|
| gptkbp:location |
liver
|
| gptkbp:orthologs |
CYP26 A1 in other species
|
| gptkbp:pathway |
retinoid metabolism
|
| gptkbp:post-translational_modification |
phosphorylation
|
| gptkbp:product |
4-oxo-retinoic acid
|
| gptkbp:promoter |
gptkb:CYP26_A1
|
| gptkbp:promotes |
retinoic acid catabolism
|
| gptkbp:regulatory_compliance |
transcription factors
|
| gptkbp:role |
drug development
retinoic acid homeostasis |
| gptkbp:sequence_length |
503 amino acids
|
| gptkbp:theory |
heme
|
| gptkbp:weight |
approximately 55 k Da
|
| gptkbp:bfsParent |
gptkb:CYP26_A1
|
| gptkbp:bfsLayer |
7
|