Statements (60)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:physicist
|
| gptkbp:activities |
Bind to retinoic acid response elements (RAR Es)
|
| gptkbp:associated_with |
Vitamin A metabolism
|
| gptkbp:clinical_trial |
Target for cancer therapy
Associated with teratogenic effects Influence on metabolic diseases Involved in skin disorders |
| gptkbp:dimensions |
Forms heterodimers with RXR
|
| gptkbp:discipline |
Inhibited by certain synthetic retinoids
|
| gptkbp:discovered_by |
Identified in the 1980s
Part of the steroid hormone receptor superfamily |
| gptkbp:established |
Activated by 9-cis retinoic acid
Activated by all-trans retinoic acid |
| gptkbp:function |
Regulate gene expression
|
| https://www.w3.org/2000/01/rdf-schema#label |
Retinoic acid receptors
|
| gptkbp:interacts_with |
Interacts with coactivators
Interacts with corepressors |
| gptkbp:is_a_route_for |
Affect bone development
Affect circadian gene expression Impact on lipid metabolism Impact on neurogenesis Influence on behavior and cognition Influence on cell cycle progression Influence on circadian rhythms Influence reproductive health Involved in the regulation of apoptosis Involved in tissue repair mechanisms Modulate inflammatory responses Part of the retinoic acid signaling pathway Regulate metabolic processes Regulate oxidative stress responses Regulate synaptic plasticity |
| gptkbp:is_involved_in |
Cell differentiation
Embryonic development Immune response |
| gptkbp:is_represented_in |
Found in various tissues
High levels in the brain High levels in the immune system High levels in the liver High levels in the skin |
| gptkbp:location |
gptkb:physicist
|
| gptkbp:origin |
Conserved across vertebrates
Diverse functions in different species |
| gptkbp:products |
Retinoic acid
|
| gptkbp:research_focus |
Effects on cardiovascular health
Interactions with other signaling pathways Mechanisms of action in cancer Role in stem cell biology |
| gptkbp:role |
Affect skin cell growth
Influence neuronal differentiation Modulate immune cell function Regulate embryonic patterning |
| gptkbp:targets |
gptkb:Hox_genes
CRABP CY P26 A1 RARB |
| gptkbp:type_of |
gptkb:RAR_(Retinoic_Acid_Receptor)
gptkb:RXR_(Retinoid_X_Receptor) |
| gptkbp:bfsParent |
gptkb:Ronald_Evans
|
| gptkbp:bfsLayer |
4
|