Statements (42)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
cytokine
|
| gptkbp:alsoKnownAs |
gptkb:Interleukin-8
|
| gptkbp:category |
signaling molecule
cytokine immune system protein |
| gptkbp:component |
extracellular space
|
| gptkbp:discoveredBy |
Yoshimura et al.
|
| gptkbp:discoveredIn |
1987
|
| gptkbp:encodedBy |
gptkb:CXCL8_gene
|
| gptkbp:Entrez_Gene_ID |
3576
ENSG00000169429 |
| gptkbp:function |
chemokine activity
chemoattractant for neutrophils mediator of inflammation |
| gptkbp:GOProcess |
immune response
neutrophil chemotaxis |
| https://www.w3.org/2000/01/rdf-schema#label |
CXCL8 (IL-8)
|
| gptkbp:involvedIn |
angiogenesis
chronic inflammation acute inflammation |
| gptkbp:locatedOnChromosome |
4q13-q21
|
| gptkbp:orthologIn |
mouse Cxcl1
mouse Cxcl2 |
| gptkbp:PDB |
1IL8
|
| gptkbp:recipient |
gptkb:CXCR2
gptkb:CXCR1 |
| gptkbp:regulates |
induced by IL-1
induced by TNF-alpha induced by bacterial products |
| gptkbp:secretes |
macrophages
endothelial cells fibroblasts epithelial cells |
| gptkbp:significance |
elevated in cancer
elevated in autoimmune diseases elevated in infection |
| gptkbp:species |
gptkb:Homo_sapiens
|
| gptkbp:structure |
8 kDa protein
72 amino acids (major form) |
| gptkbp:UniProtID |
P10145
|
| gptkbp:bfsParent |
gptkb:CXC_domain
|
| gptkbp:bfsLayer |
8
|