|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
CLN10
cathD
lysosomal aspartyl protease
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
gptkb:neuronal_ceroid_lipofuscinosis
|
|
gptkbp:biologicalProcess
|
immune response
apoptotic process
proteolysis
aspartic-type endopeptidase activity
|
|
gptkbp:cellularComponent
|
gptkb:lysosome
extracellular space
|
|
gptkbp:cleavage
|
heavy chain
light chain
|
|
gptkbp:discoveredBy
|
J. Barrett et al.
|
|
gptkbp:encodes
|
cathepsin D protein
|
|
gptkbp:Entrez_Gene_ID
|
1509
ENSG00000122024
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:firstDescribed
|
1970s
|
|
gptkbp:fullName
|
cathepsin D
|
|
gptkbp:function
|
lysosomal aspartic protease
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GOID
|
gptkb:GO:0005764
GO:0006915
GO:0004190
|
|
gptkbp:HGNC_ID
|
2511
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CTSD
|
|
gptkbp:involvedIn
|
apoptosis
protein degradation
antigen processing
|
|
gptkbp:length
|
412 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:11p15.5
|
|
gptkbp:molecularWeight
|
44 kDa (precursor)
|
|
gptkbp:mutationAssociatedWith
|
neuronal ceroid lipofuscinosis type 10
|
|
gptkbp:OMIM
|
116840
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Ctsd
|
|
gptkbp:PDB
|
1LYA
4OBZ
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:proteinFamily
|
gptkb:peptidase_A1_family
|
|
gptkbp:subcellularLocation
|
gptkb:lysosome
extracellular region
|
|
gptkbp:UniProtID
|
P07339
|
|
gptkbp:bfsParent
|
gptkb:Centre_for_Technology_in_Sustainable_Development
|
|
gptkbp:bfsLayer
|
7
|