|
gptkbp:instanceOf
|
genome editing technology
prokaryotic immune system
|
|
gptkbp:Cas3_protein_function
|
nuclease
helicase
|
|
gptkbp:Cascade_complex_function
|
target DNA recognition
|
|
gptkbp:contains
|
gptkb:CRISPR_RNA_(crRNA)
gptkb:Cas3_protein
gptkb:Cascade_complex
|
|
gptkbp:discoveredBy
|
researchers studying prokaryotic immunity
|
|
gptkbp:distinctFrom
|
gptkb:CRISPR-Cas12_system
gptkb:CRISPR-Cas9_system
|
|
gptkbp:firstDescribed
|
2005
|
|
gptkbp:foundIn
|
gptkb:Bacteria
archaea
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CRISPR-Cas3 system
|
|
gptkbp:mechanismOfAction
|
DNA interference
long-range DNA deletions
targeted DNA degradation
|
|
gptkbp:notableFeature
|
multi-protein complex
induces large genomic deletions
processive DNA degradation
|
|
gptkbp:partOf
|
gptkb:Class_1_CRISPR_systems
|
|
gptkbp:relatedTo
|
prokaryotic adaptive immunity
Type I CRISPR systems
|
|
gptkbp:requires
|
protospacer adjacent motif (PAM)
|
|
gptkbp:target
|
double-stranded DNA
|
|
gptkbp:usedFor
|
genome engineering
antiviral defense
|
|
gptkbp:usedIn
|
gptkb:biotechnology
genetic research
antimicrobial development
|
|
gptkbp:bfsParent
|
gptkb:Cas_proteins
|
|
gptkbp:bfsLayer
|
7
|