CHEMBL653

GPTKB entity

Statements (52)
Predicate Object
gptkbp:instanceOf gptkb:chemical_compound
gptkbp:approvalYear 1976
gptkbp:ATCCode gptkb:C07AB03
gptkbp:bioavailability 50% (oral)
gptkbp:CASNumber gptkb:29122-68-7
gptkbp:contraindication heart block
cardiogenic shock
sinus bradycardia
gptkbp:drugClass beta-adrenergic antagonist
antihypertensive agent
gptkbp:eliminationHalfLife 6-7 hours
gptkbp:excretion renal
gptkbp:hasInChIKey METKIMKYRPQLGS-UHFFFAOYSA-N
gptkbp:hasLogP 0.16
gptkbp:hasMolecularFormula C14H22N2O3
gptkbp:hasSMILES CC(C)NCC(COC1=CC=CC=C1O)O
gptkbp:hasUNII 50VV3VW0TI
https://www.w3.org/2000/01/rdf-schema#label CHEMBL653
gptkbp:indication gptkb:arrhythmia
hypertension
angina pectoris
gptkbp:isApprovedDrug true
gptkbp:listedOn gptkb:WHO_Model_List_of_Essential_Medicines
gptkbp:marketedIn gptkb:Canada
gptkb:Europe
gptkb:Japan
gptkb:United_Kingdom
gptkb:United_States
gptkbp:mechanismOfAction selective beta-1 adrenergic receptor blocker
gptkbp:meltingPoint 152-155°C
gptkbp:metabolism liver
gptkbp:molecularWeight 266.34
gptkbp:name gptkb:Atenolol
gptkbp:notRecommendedFor asthma
severe peripheral arterial circulatory disturbances
gptkbp:pregnancyCategory C (US)
gptkbp:proteinBinding 6-16%
gptkbp:PubChem_CID 2162
DB00335
gptkbp:routeOfAdministration oral
gptkbp:sideEffect dizziness
fatigue
bradycardia
cold extremities
gptkbp:synonym gptkb:Atenololum
gptkb:Tenormin
gptkbp:target gptkb:ADRB1
gptkb:ADRB2
gptkb:beta-2_adrenergic_receptor
beta-1 adrenergic receptor
gptkbp:bfsParent gptkb:buspirone
gptkbp:bfsLayer 7