Statements (59)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:Genetics
|
| gptkbp:affects |
gptkb:CHEK2_gene
|
| gptkbp:associated_with |
gptkb:Oncology
|
| gptkbp:can_lead_to |
loss of function
tumorigenesis |
| gptkbp:discovered_by |
human population
|
| gptkbp:first_described_by |
2000s
|
| https://www.w3.org/2000/01/rdf-schema#label |
CHEK2*1100del C
|
| gptkbp:included |
genetic databases
|
| gptkbp:influences |
DNA repair mechanisms
|
| gptkbp:investigates |
therapeutic interventions
molecular biology research |
| gptkbp:is_a |
deletion mutation
|
| gptkbp:is_analyzed_in |
biomedical research
population studies genetic epidemiology studies |
| gptkbp:is_associated_with |
increased surveillance
family history of cancer early detection methods |
| gptkbp:is_common_in |
certain populations
|
| gptkbp:is_considered |
risk assessment
treatment planning family planning decisions personalized medicine approaches |
| gptkbp:is_considered_as |
risk factor for cancer
|
| gptkbp:is_discussed_in |
gptkb:literature
patient education materials oncology conferences |
| gptkbp:is_evaluated_by |
clinical trials
treatment options screening recommendations |
| gptkbp:is_examined_in |
clinical studies
longitudinal studies clinical implications |
| gptkbp:is_linked_to |
increased cancer risk
lifestyle modifications genetic counseling prognosis of cancer |
| gptkbp:is_located_in |
chromosome 22
|
| gptkbp:is_monitored_by |
cancer patients
|
| gptkbp:is_part_of |
gptkb:hereditary_breast_and_ovarian_cancer_syndrome
cancer prevention strategies genetic predisposition to cancer cancer genetics research cancer risk management strategies CHEK2 gene mutations |
| gptkbp:is_recognized_by |
genetic testing
next-generation sequencing |
| gptkbp:is_related_to |
BRCA1 and BRCA2 mutations
|
| gptkbp:is_studied_for |
preventive measures
risk reduction strategies |
| gptkbp:is_studied_in |
cancer research
|
| gptkbp:is_tested_for |
hereditary cancer syndromes
|
| gptkbp:prevalence |
gptkb:Ashkenazi_Jewish_population
|
| gptkbp:reported_by |
case studies
genetic counseling guidelines |
| gptkbp:type_of |
gptkb:Genetics
|
| gptkbp:bfsParent |
gptkb:CHEK2
|
| gptkbp:bfsLayer |
6
|