|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
CES2A
CES2A1
hCE-2
|
|
gptkbp:component
|
endoplasmic reticulum lumen
|
|
gptkbp:encodes
|
carboxylesterase 2 enzyme
|
|
gptkbp:Entrez_Gene_ID
|
8824
|
|
gptkbp:enzymeCommissionNumber
|
gptkb:EC_3.1.1.1
|
|
gptkbp:expressedIn
|
gptkb:kidney
liver
colon
intestine
|
|
gptkbp:foundIn
|
gptkb:endoplasmic_reticulum
|
|
gptkbp:fullName
|
carboxylesterase 2
|
|
gptkbp:function
|
carboxylic ester hydrolase activity
hydrolyzes ester- and amide-bond-containing drugs
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GOProcess
|
xenobiotic metabolic process
|
|
gptkbp:HGNC_ID
|
1863
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CES2
|
|
gptkbp:involvedIn
|
detoxification of xenobiotics
activation of prodrugs
|
|
gptkbp:length
|
14 exons
|
|
gptkbp:locatedOnChromosome
|
16q13-q22.1
|
|
gptkbp:molecularWeight
|
~60 kDa
|
|
gptkbp:mutationAssociatedWith
|
variation in drug response
|
|
gptkbp:OMIM
|
601309
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Ces2
|
|
gptkbp:proteinFamily
|
gptkb:carboxylesterase_family
|
|
gptkbp:regulates
|
induced by xenobiotics
regulated by nuclear receptors
|
|
gptkbp:relatedTo
|
drug metabolism
xenobiotic metabolism
|
|
gptkbp:sequenceReference
|
NCBI Reference Sequence: NM_003869
|
|
gptkbp:significance
|
pharmacogenomics
cancer chemotherapy response
drug toxicity
|
|
gptkbp:structure
|
contains alpha/beta hydrolase fold
|
|
gptkbp:substrate
|
gptkb:clopidogrel
gptkb:irinotecan
gptkb:oseltamivir
gptkb:methylphenidate
cocaine
amphetamine
nicotine esters
various esters and amides
|
|
gptkbp:UniProtID
|
O00748
|
|
gptkbp:bfsParent
|
gptkb:carboxylesterase_family
|
|
gptkbp:bfsLayer
|
8
|