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gptkbp:instanceOf
|
gptkb:protein
|
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gptkbp:alsoKnownAs
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gptkb:CTCF
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gptkbp:associatedWith
|
gptkb:cancer
intellectual disability
chromatin looping
|
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gptkbp:conservedIn
|
vertebrates
|
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gptkbp:contains
|
zinc finger domains
|
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gptkbp:discoveredIn
|
1990s
|
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gptkbp:encodedBy
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gptkb:CTCF_gene
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gptkbp:foundIn
|
gptkb:Homo_sapiens
|
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gptkbp:function
|
regulation of gene expression
transcriptional regulator
chromatin insulator
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CCCTC-binding factor C
|
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gptkbp:interactsWith
|
gptkb:RNA_polymerase_II
gptkb:YY1
gptkb:cohesin_complex
|
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gptkbp:length
|
727
|
|
gptkbp:locale
|
gptkb:nucleus
|
|
gptkbp:locatedOnChromosome
|
16q22.1
|
|
gptkbp:molecularWeight
|
~82 kDa
|
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gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
poly(ADP-ribosyl)ation
|
|
gptkbp:regulates
|
transcriptional activation
transcriptional repression
chromatin architecture
enhancer blocking
imprinting of IGF2/H19 locus
topologically associating domains (TADs)
|
|
gptkbp:requires
|
embryonic development
|
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gptkbp:bfsParent
|
gptkb:CTCFC
|
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gptkbp:bfsLayer
|
7
|