Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alternativeName |
gptkb:C-CBL
gptkb:RNF55 proto-oncogene c-Cbl |
| gptkbp:associatedWith |
gptkb:juvenile_myelomonocytic_leukemia
gptkb:Noonan_syndrome-like_disorder |
| gptkbp:discoveredBy |
gptkb:Hidesaburo_Hanafusa
|
| gptkbp:encodes |
CBL proto-oncogene protein
|
| gptkbp:Entrez_Gene_ID |
867
|
| gptkbp:expressedIn |
various tissues
|
| gptkbp:function |
E3 ubiquitin-protein ligase activity
|
| gptkbp:HGNC_ID |
1541
|
| https://www.w3.org/2000/01/rdf-schema#label |
CBL (gene)
|
| gptkbp:involvedIn |
signal transduction
negative regulation of protein tyrosine kinase activity |
| gptkbp:locatedOnChromosome |
chromosome 11
|
| gptkbp:mutationAssociatedWith |
oncogenic transformation
|
| gptkbp:OMIM |
165360
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologInMouse |
Cbl (mouse gene)
|
| gptkbp:proteinFamily |
SH2 domain
RING finger domain proline-rich region |
| gptkbp:regulates |
gptkb:receptor_tyrosine_kinases
cell signaling pathways |
| gptkbp:UniProtID |
P22681
|
| gptkbp:bfsParent |
gptkb:CBL
|
| gptkbp:bfsLayer |
7
|