|
gptkbp:instanceOf
|
benzodiazepine
general anesthetic
|
|
gptkbp:aroma
|
odorless
|
|
gptkbp:ATCCode
|
N01AF03
|
|
gptkbp:CASNumber
|
76-75-5
|
|
gptkbp:chemical_compound
|
C11H18N2O2S
|
|
gptkbp:color
|
white to pale yellow powder
|
|
gptkbp:contraindication
|
porphyria
severe cardiovascular disease
|
|
gptkbp:discoveredBy
|
gptkb:Donalee_L._Tabern
gptkb:Ernest_H._Volwiler
1934
|
|
gptkbp:drugClass
|
ultra-short-acting barbiturates
|
|
gptkbp:eliminationHalfLife
|
5-11 hours
|
|
gptkbp:excretion
|
gptkb:kidney
|
|
gptkbp:form
|
usually as sodium thiopental
|
|
gptkbp:has_protein_binding
|
72-86%
|
|
gptkbp:has_trade_name
|
gptkb:Pentothal
|
|
gptkbp:hasInChIKey
|
BSYNRYMUTXBXSQ-UHFFFAOYSA-N
|
|
gptkbp:hasSMILES
|
O=C1NC(=S)NC(=O)C1(CC)C(C)CCC
|
|
gptkbp:hasUNII
|
4H1K3J149L
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Thiopental
|
|
gptkbp:IUPACName
|
5-ethyl-5-(1-methylbutyl)-2-thiobarbituric acid
|
|
gptkbp:KEGGID
|
D00541
|
|
gptkbp:legalStatus
|
gptkb:Schedule_III_(US)
Prescription only (various countries)
|
|
gptkbp:mechanismOfAction
|
GABA-A receptor agonist
|
|
gptkbp:meltingPoint
|
163°C
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
242.34 g/mol
|
|
gptkbp:pKa
|
7.6
|
|
gptkbp:PubChem_CID
|
5355
9506
5163
CHEMBL1200727
DB00599
|
|
gptkbp:routeOfAdministration
|
intravenous
|
|
gptkbp:sideEffect
|
hypotension
respiratory depression
myocardial depression
|
|
gptkbp:solubility
|
soluble in water (as sodium salt)
|
|
gptkbp:used_in_capital_punishment
|
yes
|
|
gptkbp:used_in_euthanasia
|
yes
|
|
gptkbp:used_in_veterinary_medicine
|
yes
|
|
gptkbp:usedFor
|
lethal injection
sedation
induction of anesthesia
medically induced coma
|
|
gptkbp:bfsParent
|
gptkb:Barbiturates
|
|
gptkbp:bfsLayer
|
7
|