|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:Bloom_syndrome_protein
gptkb:RECQL3
RecQ-like helicase
|
|
gptkbp:associatedWith
|
gptkb:Bloom_syndrome
|
|
gptkbp:biologicalProcess
|
ATP binding
DNA binding
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
|
|
gptkbp:discoveredBy
|
gptkb:James_German
|
|
gptkbp:discoveredIn
|
1995
|
|
gptkbp:enzymeClassification
|
gptkb:EC_3.6.4.12
|
|
gptkbp:formsComplexWith
|
gptkb:RMI1
gptkb:RMI2
gptkb:TOP3A
BLAP75
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
gptkb:DNA_helicase
DNA repair
homologous recombination
|
|
gptkbp:gene
|
gptkb:BLM
gptkb:BLM_gene
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
BLM helicase
|
|
gptkbp:interactsWith
|
gptkb:RMI1
gptkb:RMI2
gptkb:TOP3A
gptkb:FANCM
gptkb:BRCA1
gptkb:RAD51
|
|
gptkbp:involves
|
DNA double-strand break repair
replication fork processing
|
|
gptkbp:length
|
1417
|
|
gptkbp:locatedOnChromosome
|
gptkb:15q26.1
|
|
gptkbp:molecularWeight
|
159 kDa
|
|
gptkbp:mutationAssociatedWith
|
increased cancer risk
genomic instability
|
|
gptkbp:OMIM
|
604610
|
|
gptkbp:orthologInMouse
|
Blm
|
|
gptkbp:orthologInYeast
|
Sgs1
|
|
gptkbp:PDB
|
gptkb:4CGZ
4O3M
4O3N
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
ubiquitination
|
|
gptkbp:regulates
|
sister chromatid exchange
genome stability
|
|
gptkbp:reviewedBy
|
gptkb:Nucleic_Acids_Research
gptkb:Nature_Reviews_Cancer
Cell
|
|
gptkbp:UniProtID
|
P54132
|
|
gptkbp:bfsParent
|
gptkb:Bloom_syndrome_protein
|
|
gptkbp:bfsLayer
|
7
|