Aspartate aminotransferase

URI: https://gptkb.org/entity/Aspartate_aminotransferase
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:abbreviation gptkb:SGOT
AST
gptkbp:alternativeName gptkb:glutamate_oxaloacetate_transaminase
aspartate transaminase
gptkbp:CASNumber 9000-97-9
gptkbp:catalyzes transfer of amino group from aspartate to alpha-ketoglutarate
gptkbp:clinical_use marker for myocardial infarction
marker for liver damage
gptkbp:cofactor gptkb:pyridoxal_phosphate
gptkbp:decreasedIn gptkb:vitamin_B6_deficiency
gptkbp:EC_number 2.6.1.1
gptkbp:enzymeClassification transferase
gptkbp:firstDescribed 1955
gptkbp:foundIn gptkb:skeletal_muscle
gptkb:kidney
brain
heart
liver
gptkbp:gene gptkb:GOT1
gptkb:GOT2
gptkbp:gene_location_(GOT1) chromosome 10q24.1
gptkbp:gene_location_(GOT2) chromosome 16q21
gptkbp:increased_in myocardial infarction
cirrhosis
hepatitis
muscle injury
gptkbp:inhibitedBy gptkb:aminooxyacetate
hydrazine
gptkbp:involves gptkb:urea_cycle
amino acid metabolism
gluconeogenesis
gptkbp:measures gptkb:blood_test
gptkbp:molecularWeight ~45 kDa (per subunit)
gptkbp:optimum_pH 7.4
gptkbp:PDB gptkb:1AJS
gptkbp:product gptkb:oxaloacetate
glutamate
gptkbp:reference_range_(serum) 10–40 U/L (adults)
gptkbp:relatedTo gptkb:alanine_aminotransferase
gptkbp:structure homodimer
gptkbp:subcellularLocation gptkb:cytoplasm
mitochondria
gptkbp:UniProtID P17174
gptkbp:used_in liver function tests
cardiac enzyme tests
gptkbp:bfsParent gptkb:Aminotransferase
gptkbp:bfsLayer 7
https://www.w3.org/2000/01/rdf-schema#label Aspartate aminotransferase