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Aspartate aminotransferase
URI:
https://gptkb.org/entity/Aspartate_aminotransferase
GPTKB entity
Statements (50)
Predicate
Object
gptkbp:instanceOf
gptkb:enzyme
gptkbp:abbreviation
gptkb:SGOT
AST
gptkbp:alternativeName
gptkb:glutamate_oxaloacetate_transaminase
aspartate transaminase
gptkbp:CASNumber
9000-97-9
gptkbp:catalyzes
transfer of amino group from aspartate to alpha-ketoglutarate
gptkbp:clinical_use
marker for myocardial infarction
marker for liver damage
gptkbp:cofactor
gptkb:pyridoxal_phosphate
gptkbp:decreasedIn
gptkb:vitamin_B6_deficiency
gptkbp:EC_number
2.6.1.1
gptkbp:enzymeClassification
transferase
gptkbp:firstDescribed
1955
gptkbp:foundIn
gptkb:skeletal_muscle
gptkb:kidney
brain
heart
liver
gptkbp:gene
gptkb:GOT1
gptkb:GOT2
gptkbp:gene_location_(GOT1)
chromosome 10q24.1
gptkbp:gene_location_(GOT2)
chromosome 16q21
https://www.w3.org/2000/01/rdf-schema#label
Aspartate aminotransferase
gptkbp:increased_in
myocardial infarction
cirrhosis
hepatitis
muscle injury
gptkbp:inhibitedBy
gptkb:aminooxyacetate
hydrazine
gptkbp:involves
gptkb:urea_cycle
amino acid metabolism
gluconeogenesis
gptkbp:measures
blood test
gptkbp:molecularWeight
~45 kDa (per subunit)
gptkbp:optimum_pH
7.4
gptkbp:PDB
gptkb:1AJS
gptkbp:product
gptkb:oxaloacetate
glutamate
gptkbp:reference_range_(serum)
10–40 U/L (adults)
gptkbp:relatedTo
gptkb:alanine_aminotransferase
gptkbp:structure
homodimer
gptkbp:subcellularLocation
gptkb:cytoplasm
mitochondria
gptkbp:UniProtID
P17174
gptkbp:used_in
liver function tests
cardiac enzyme tests
gptkbp:bfsParent
gptkb:1AXC
gptkb:Aminotransferase
gptkbp:bfsLayer
7