|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
water channel protein
|
|
gptkbp:associatedWith
|
gptkb:Sjögren's_syndrome
gptkb:nephrogenic_diabetes_insipidus
glaucoma
brain edema
|
|
gptkbp:discoveredBy
|
gptkb:Peter_Agre
|
|
gptkbp:energyEfficiency
|
no ATP required
|
|
gptkbp:essentialResidues
|
NPA motif
|
|
gptkbp:firstDescribed
|
1992
|
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gptkbp:foundIn
|
gptkb:cell_membrane
gptkb:Bacteria
animals
plants
|
|
gptkbp:function
|
water transport
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Aquaporin
|
|
gptkbp:molecularWeight
|
~28 kDa
|
|
gptkbp:NobelPrizeYear
|
2003 Nobel Prize in Chemistry
|
|
gptkbp:permeableTo
|
selective for water
some permeable to glycerol
|
|
gptkbp:poreDiameter
|
~2.8 Å
|
|
gptkbp:proteinFamily
|
gptkb:AQP
|
|
gptkbp:publicTransit
|
passive
|
|
gptkbp:regulates
|
gptkb:vasopressin
|
|
gptkbp:roleInBrain
|
cerebrospinal fluid homeostasis
|
|
gptkbp:roleInEye
|
lens transparency
|
|
gptkbp:roleInFatTissue
|
glycerol transport
|
|
gptkbp:roleInKidney
|
urine concentration
|
|
gptkbp:roleInLiver
|
ammonia detoxification
|
|
gptkbp:roleInLung
|
airway hydration
|
|
gptkbp:roleInPlants
|
regulate water uptake
|
|
gptkbp:roleInRedBloodCells
|
water homeostasis
|
|
gptkbp:roleInSalivaryGlands
|
saliva secretion
|
|
gptkbp:roleInSkin
|
skin hydration
|
|
gptkbp:roleInTestis
|
sperm maturation
|
|
gptkbp:structure
|
tetramer
|
|
gptkbp:subspecies
|
AQP4
AQP3
AQP1
AQP10
AQP11
AQP12
AQP2
AQP5
AQP6
AQP7
AQP8
AQP9
|
|
gptkbp:transmembraneDomains
|
6
|
|
gptkbp:bfsParent
|
gptkb:Membrane_Channels
|
|
gptkbp:bfsLayer
|
7
|