Amyotrophic lateral sclerosis (ALS)

URI: https://gptkb.org/entity/Amyotrophic_lateral_sclerosis_(ALS)
GPTKB entity
Statements (56)
Predicate Object
gptkbp:instanceOf neurodegenerative disease
motor neuron disease
gptkbp:affects lower motor neurons
motor neurons
upper motor neurons
gptkbp:alsoKnownAs gptkb:Lou_Gehrig's_disease
gptkbp:averageSurvivalAfterDiagnosis 2 to 5 years
gptkbp:casualties yes
gptkbp:cause difficulty breathing
difficulty speaking
difficulty swallowing
muscle atrophy
muscle weakness
gptkbp:diagnosedBy gptkb:electromyography_(EMG)
MRI
clinical examination
nerve conduction studies
gptkbp:differentialDiagnosis multiple sclerosis
spinal muscular atrophy
primary lateral sclerosis
progressive muscular atrophy
gptkbp:field neurology
gptkbp:firstDescribed gptkb:Jean-Martin_Charcot
1869
gptkbp:hereditaryCases 5-10%
https://www.w3.org/2000/01/rdf-schema#label Amyotrophic lateral sclerosis (ALS)
gptkbp:ICD-10_code G12.2
gptkbp:incidence about 2 per 100,000 people per year
gptkbp:MeSH_ID D000690
gptkbp:mutationAssociatedWith gptkb:C9orf72
gptkb:FUS
gptkb:SOD1
gptkb:TARDBP
gptkbp:namedAfter gptkb:Lou_Gehrig
gptkbp:notablePatient gptkb:Stephen_Hawking
gptkb:Lou_Gehrig
Astrocyte dysfunction
gptkbp:OMIM 105400
gptkbp:onset adulthood
gptkbp:prevalence rare
gptkbp:progression progressive
gptkbp:riskFactor age
family history
male sex
gptkbp:sporadicCases 90-95%
gptkbp:studiedBy gptkb:ALS_Ice_Bucket_Challenge
gptkbp:symptom respiratory failure
weight loss
spasticity
muscle cramps
fasciculations
gptkbp:treatment gptkb:edaravone
gptkb:riluzole
supportive care
gptkbp:bfsParent gptkb:Henry_Wallace
gptkbp:bfsLayer 5