|
gptkbp:instanceOf
|
antifungal medication
polyene antifungal
|
|
gptkbp:approvedBy
|
gptkb:FDA
|
|
gptkbp:ATCCode
|
gptkb:J02AA01
|
|
gptkbp:brand
|
gptkb:Abelcet
gptkb:AmBisome
gptkb:Fungizone
Amphocil
|
|
gptkbp:CASNumber
|
gptkb:1397-89-3
|
|
gptkbp:contraindication
|
hypersensitivity to amphotericin B
|
|
gptkbp:discoveredBy
|
gptkb:Squibb_Institute_for_Medical_Research
|
|
gptkbp:discoveredIn
|
1955
|
|
gptkbp:eliminationHalfLife
|
15 days
|
|
gptkbp:form
|
gptkb:liposomal_amphotericin_B
gptkb:amphotericin_B_colloidal_dispersion
gptkb:amphotericin_B_lipid_complex
gptkb:conventional_amphotericin_B
|
|
gptkbp:hasMolecularFormula
|
C47H73NO17
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Amphotericin B
|
|
gptkbp:KEGGID
|
gptkb:D00203
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
binds to ergosterol in fungal cell membranes
forms pores in fungal cell membranes
|
|
gptkbp:MedlinePlusID
|
a682643
|
|
gptkbp:meltingPoint
|
170°C
|
|
gptkbp:molecularWeight
|
924.08 g/mol
|
|
gptkbp:origin
|
gptkb:Streptomyces_nodosus
|
|
gptkbp:pregnancyCategory
|
B (US)
|
|
gptkbp:PubChem_CID
|
gptkb:CHEMBL521
gptkb:DB00681
5280965
|
|
gptkbp:routeOfAdministration
|
topical
intravenous
|
|
gptkbp:sideEffect
|
gptkb:anemia
fever
chills
hypokalemia
nephrotoxicity
|
|
gptkbp:solubility
|
insoluble in water
soluble in DMSO
soluble in methanol
|
|
gptkbp:synonym
|
gptkb:Abelcet
gptkb:AmBisome
gptkb:Fungizone
Amphocil
|
|
gptkbp:UNII
|
J6292F8L3D
|
|
gptkbp:usedFor
|
treatment of fungal infections
treatment of leishmaniasis
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
true
|
|
gptkbp:bfsParent
|
gptkb:Streptomyces_species
|
|
gptkbp:bfsLayer
|
6
|