Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:CASNumber |
37288-57-2
|
| gptkbp:deficiencyCauses |
gptkb:Hurler_syndrome
gptkb:Scheie_syndrome gptkb:Mucopolysaccharidosis_type_I |
| gptkbp:EC_number |
3.2.1.76
|
| gptkbp:enzymeClassification |
glycoside hydrolase family 39
|
| gptkbp:foundIn |
gptkb:Homo_sapiens
|
| gptkbp:function |
hydrolyzes terminal alpha-L-iduronic acid residues
degrades glycosaminoglycans |
| gptkbp:gene |
gptkb:IDUA
|
| gptkbp:hasApprovedDrug |
gptkb:laronidase
|
| https://www.w3.org/2000/01/rdf-schema#label |
Alpha-L-iduronidase
|
| gptkbp:involvedIn |
lysosomal degradation
|
| gptkbp:location |
gptkb:lysosome
|
| gptkbp:molecularWeight |
83 kDa
|
| gptkbp:OMIM |
252800
|
| gptkbp:structure |
gptkb:protein
|
| gptkbp:substrate |
dermatan sulfate
heparan sulfate |
| gptkbp:UniProtID |
P35475
|
| gptkbp:bfsParent |
gptkb:IDUA_HUMAN
|
| gptkbp:bfsLayer |
7
|