|
gptkbp:instanceOf
|
gptkb:drug
xanthine oxidase inhibitor
|
|
gptkbp:affects
|
uric acid production
|
|
gptkbp:approvedInUS
|
1966
|
|
gptkbp:ATCCode
|
M04AA01
|
|
gptkbp:availableOn
|
gptkb:tablet
injectable
|
|
gptkbp:brand
|
Aloprim
Zyloprim
|
|
gptkbp:CASNumber
|
315-30-0
|
|
gptkbp:category
|
gptkb:enzyme
purine analog
antigout agent
|
|
gptkbp:chemicalFormula
|
C5H4N4O
|
|
gptkbp:combines
|
gptkb:NSAIDs
colchicine
|
|
gptkbp:contraindication
|
severe renal impairment
allergy to allopurinol
|
|
gptkbp:discoveredBy
|
Roland K. Robins
|
|
gptkbp:discoveredIn
|
1956
|
|
gptkbp:eliminationHalfLife
|
1-2 hours
|
|
gptkbp:excretion
|
urine
|
|
gptkbp:firstSynthesized
|
1956
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Allopurinol
|
|
gptkbp:interactsWith
|
gptkb:theophylline
gptkb:warfarin
azathioprine
mercaptopurine
|
|
gptkbp:legalStatus
|
prescription only
off-patent
|
|
gptkbp:mechanismOfAction
|
inhibits xanthine oxidase
|
|
gptkbp:MedlinePlusID
|
a682673
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:molecularWeight
|
136.11 g/mol
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:PubChem_CID
|
2094
DB00437
|
|
gptkbp:riskFactor
|
renal failure
bone marrow suppression
hypersensitivity syndrome
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
gptkb:Stevens-Johnson_syndrome
allergic reaction
rash
liver dysfunction
|
|
gptkbp:UNII
|
53U0H19RTK
|
|
gptkbp:usedFor
|
gptkb:tumor_lysis_syndrome
gout
hyperuricemia
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
included
|
|
gptkbp:bfsParent
|
gptkb:Zentiva
|
|
gptkbp:bfsLayer
|
7
|