Statements (54)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:G_protein-coupled_receptor |
| gptkbp:activatedBy |
gptkb:Gs_protein
|
| gptkbp:binds |
gptkb:adenosine
|
| gptkbp:drugClass |
purinergic receptor
|
| gptkbp:encodedBy |
ADORA2A gene
|
| gptkbp:enemyOf |
gptkb:regadenoson
caffeine CGS-21680 istradefylline |
| gptkbp:expressedIn |
brain
heart immune cells |
| gptkbp:formsComplexWith |
dopamine D2 receptor
|
| gptkbp:foundIn |
gptkb:striatum
|
| https://www.w3.org/2000/01/rdf-schema#label |
Adenosine A2a receptor
|
| gptkbp:improves |
cAMP production
|
| gptkbp:involvedIn |
immunosuppression
neurotransmission sleep regulation cardioprotection vasodilation inflammation modulation |
| gptkbp:locatedIn |
gptkb:cell_membrane
|
| gptkbp:locatedOnChromosome |
22q11.23
|
| gptkbp:modulatedBy |
immune response
motor control platelet aggregation glutamate release T cell activity GABAergic transmission cholinergic transmission histaminergic transmission microglial activation noradrenergic transmission serotonergic transmission |
| gptkbp:molecularWeight |
45 kDa
|
| gptkbp:OMIM |
102776
|
| gptkbp:PDB |
3EML
|
| gptkbp:regulates |
dopamine signaling
|
| gptkbp:relatedTo |
Adenosine A1 receptor
Adenosine A2b receptor Adenosine A3 receptor |
| gptkbp:target |
immunotherapy
anti-inflammatory drugs antiparkinsonian drugs ischemia therapies |
| gptkbp:transmembraneDomains |
true
|
| gptkbp:UniProtID |
P29274
|
| gptkbp:bfsParent |
gptkb:CHEMBL1230992
gptkb:CHEMBL1743027 gptkb:CHEMBL1743088 gptkb:CHEMBL2104662 |
| gptkbp:bfsLayer |
8
|