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gptkbp:instanceOf
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gptkb:disease
leukemia
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gptkbp:abbreviation
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gptkb:AML
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gptkbp:affects
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blood
bone marrow
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gptkbp:causedBy
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genetic mutations
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gptkbp:commonIn
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adults
children
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gptkbp:diagnosedBy
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bone marrow biopsy
blood tests
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gptkbp:firstDescribed
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early 20th century
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gptkbp:guidanceSystem
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gptkb:NCCN_Guidelines
gptkb:WHO_Classification
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gptkbp:hasGeneticMarker
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gptkb:CEBPA_mutation
gptkb:FLT3_mutation
gptkb:IDH1/2_mutation
gptkb:NPM1_mutation
gptkb:RUNX1_mutation
gptkb:t(8;21)_translocation
inv(16) inversion
t(15;17) translocation
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https://www.w3.org/2000/01/rdf-schema#label
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Acute Myeloid Leukemia
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gptkbp:ICD-10_code
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gptkb:C92.0
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gptkbp:mortalityRate
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high
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gptkbp:originatedIn
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myeloid lineage
hematopoietic stem cells
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gptkbp:prognosis
|
varies by age and genetics
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gptkbp:relapseRate
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significant
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gptkbp:relatedTo
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gptkb:chronic_myeloid_leukemia
leukemia
myelodysplastic syndromes
|
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gptkbp:riskFactor
|
exposure to radiation
genetic disorders
older age
previous chemotherapy
exposure to chemicals
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gptkbp:subspecies
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gptkb:acute_erythroid_leukemia
gptkb:acute_megakaryoblastic_leukemia
gptkb:acute_monocytic_leukemia
gptkb:acute_myelomonocytic_leukemia
gptkb:acute_promyelocytic_leukemia
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gptkbp:symptom
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gptkb:anemia
fever
fatigue
easy bruising
frequent infections
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gptkbp:treatment
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radiation therapy
chemotherapy
targeted therapy
stem cell transplant
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gptkbp:bfsParent
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gptkb:AML
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gptkbp:bfsLayer
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5
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