|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activeSiteResidue
|
catalytic triad
|
|
gptkbp:alternativeName
|
gptkb:AChE
gptkb:acetylcholine_hydrolase
|
|
gptkbp:catalyzes
|
hydrolysis of acetylcholine
|
|
gptkbp:crystal_structure_determined
|
1991
|
|
gptkbp:discoveredBy
|
gptkb:Henry_Dale
|
|
gptkbp:discoveredIn
|
1932
|
|
gptkbp:EC_number
|
3.1.1.7
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
erythrocytes
nerve tissue
|
|
gptkbp:family
|
gptkb:carboxylesterase_family
|
|
gptkbp:foundIn
|
central nervous system
neuromuscular junctions
red blood cell membranes
|
|
gptkbp:gene
|
gptkb:ACHE
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Acetylcholinesterase
|
|
gptkbp:inhibitedBy
|
gptkb:neostigmine
gptkb:physostigmine
gptkb:organophosphates
gptkb:edrophonium
carbamates
accumulation of acetylcholine
|
|
gptkbp:inhibition_causes
|
cholinergic crisis
muscle overstimulation
|
|
gptkbp:molecularWeight
|
~70 kDa
|
|
gptkbp:PDB
|
gptkb:1B41
|
|
gptkbp:presentIn
|
some bacteria
some plants
all animals
|
|
gptkbp:product
|
gptkb:choline
acetate
|
|
gptkbp:requires
|
termination of synaptic transmission
|
|
gptkbp:significance
|
target for insecticides
target for nerve agents
target for Alzheimer's drugs
|
|
gptkbp:structure
|
serine hydrolase
|
|
gptkbp:substrate
|
gptkb:acetylcholine
|
|
gptkbp:subunit
|
monomeric or oligomeric
|
|
gptkbp:type
|
reversible
irreversible
|
|
gptkbp:UniProtID
|
gptkb:P22303_(human)
|
|
gptkbp:used_in
|
treatment of glaucoma
diagnosis of myasthenia gravis
treatment of Alzheimer's disease
treatment of anticholinergic toxicity
treatment of myasthenia gravis
|
|
gptkbp:bfsParent
|
gptkb:Enzymes
|
|
gptkbp:bfsLayer
|
6
|