Statements (99)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:drug
|
| gptkbp:alsoKnownAs |
gptkb:cediranib
|
| gptkbp:CASNumber |
288383-20-0
|
| gptkbp:clinicalTrialPhase |
Phase III
|
| gptkbp:developedBy |
gptkb:AstraZeneca
|
| gptkbp:hasMolecularFormula |
C25H27N5O3
|
| gptkbp:indication |
gptkb:cancer
|
| gptkbp:mechanismOfAction |
VEGFR tyrosine kinase inhibitor
|
| gptkbp:molecularWeight |
445.51 g/mol
|
| gptkbp:PubChem_CID |
9933476
CHEMBL297594 |
| gptkbp:routeOfAdministration |
oral
|
| gptkbp:sideEffect |
gptkb:peripheral_neuropathy
gptkb:pneumonia gptkb:encephalopathy gptkb:seizure gptkb:glaucoma gptkb:visual_disturbance confusion heart failure myocardial infarction nausea stroke vomiting diarrhea abdominal pain anorexia constipation dizziness fatigue headache hypertension pulmonary embolism sepsis urinary tract infection back pain gastrointestinal bleeding weight loss alopecia dehydration cough proteinuria hypothyroidism blurred vision rash QT prolongation elevated liver enzymes hypokalemia insomnia neutropenia hyponatremia thrombocytopenia intestinal obstruction dyspepsia dyspnea leukopenia arthralgia hyperglycemia myalgia renal impairment intestinal perforation pericardial effusion dry skin hemorrhage decreased appetite upper respiratory tract infection venous thromboembolism epistaxis pyrexia deep vein thrombosis dysgeusia febrile neutropenia hypomagnesemia hypocalcemia peripheral edema retinal detachment stomatitis hypertensive crisis gastrointestinal perforation hyperuricemia asthenia cardiac dysfunction fistula formation retinal hemorrhage dysphonia arterial thromboembolism hemorrhagic events mucosal inflammation palmar-plantar erythrodysesthesia syndrome posterior reversible encephalopathy syndrome reversible posterior leukoencephalopathy syndrome wound healing complications |
| gptkbp:target |
gptkb:VEGFR-1
gptkb:VEGFR-2 gptkb:VEGFR-3 |
| gptkbp:UNII |
6UKA5VEJ6Z
|
| gptkbp:bfsParent |
gptkb:cediranib
|
| gptkbp:bfsLayer |
7
|
| https://www.w3.org/2000/01/rdf-schema#label |
AZD2171
|