Statements (58)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:associated_with |
environmental factors
genetic predisposition poor prognosis treatment resistance myeloid malignancies |
| gptkbp:breeding_range |
chromosome 20
|
| gptkbp:clinical_trial |
biomarker for prognosis
|
| gptkbp:diseases |
gptkb:myelodysplastic_syndromes
gptkb:Oncology gptkb:chronic_myelomonocytic_leukemia solid tumors |
| gptkbp:function |
regulates gene expression
|
| gptkbp:genetic_studies |
frameshift mutations
linked to cancer missense mutations nonsense mutations |
| https://www.w3.org/2000/01/rdf-schema#label |
ASXL1 protein
|
| gptkbp:initiated_by |
cell proliferation
|
| gptkbp:interacts_with |
other proteins
|
| gptkbp:involved_in |
DNA damage response
cell cycle regulation cell differentiation developmental processes immune response metabolic processes cell signaling pathways epigenetic regulation |
| gptkbp:is_expressed_in |
varies in different tissues
higher in stem cells lower in differentiated cells |
| gptkbp:is_recognized_by |
blood samples
tumor samples bone marrow samples cancer samples |
| gptkbp:is_studied_for |
therapeutic interventions
diagnostic purposes biological functions molecular mechanisms prognostic markers |
| gptkbp:is_studied_in |
clinical trials
|
| gptkbp:is_targeted_at |
gptkb:gene_therapy
gptkb:CRISPR_technology gptkb:monoclonal_antibody small molecules |
| gptkbp:location |
gptkb:Atom
|
| gptkbp:orthologs |
found in multiple species
|
| gptkbp:pathway |
Wnt signaling pathway
Hedgehog signaling pathway Notch signaling pathway |
| gptkbp:promoter |
gptkb:ASXL1
|
| gptkbp:promotes |
apoptosis
|
| gptkbp:research |
target for cancer therapy
|
| gptkbp:role |
chromatin remodeling
transcriptional regulation |
| gptkbp:type |
tumor suppressor
|
| gptkbp:bfsParent |
gptkb:ASXL1
|
| gptkbp:bfsLayer |
6
|