ASCL2

GPTKB entity

Statements (36)
Predicate Object
gptkbp:instanceOf gptkb:gene
gptkbp:alsoKnownAs gptkb:MASH2
gptkb:bHLHa45
gptkbp:associatedWith gptkb:cancer
colorectal cancer
gptkbp:discoveredBy homology to Drosophila achaete-scute complex
gptkbp:encodes gptkb:achaete-scute_homolog_2
gptkbp:Entrez_Gene_ID 431
ENSG00000143119
gptkbp:expressedIn gptkb:placenta
brain
colon
gptkbp:fullName gptkb:Achaete-scute_family_bHLH_transcription_factor_2
gptkbp:function transcription factor
regulation of cell fate determination
regulation of placental development
gptkbp:geneType protein-coding
gptkbp:HGNC_ID HGNC:739
https://www.w3.org/2000/01/rdf-schema#label ASCL2
gptkbp:imprintedGene yes
gptkbp:locatedOnChromosome gptkb:human_chromosome_11
gptkb:11p15.5
gptkbp:molecularWeight 21.6 kDa
gptkbp:OMIM 602337
gptkbp:orthologInMouse gptkb:Ascl2
gptkbp:parentalExpression maternally imprinted (paternally expressed)
gptkbp:regulates gptkb:Wnt_signaling_pathway
stem cell maintenance
basic helix-loop-helix (bHLH)
trophoblast development
gptkbp:relatedTo neurogenesis
intestinal stem cell identity
gptkbp:sequence 193 amino acids
gptkbp:UniProtID Q99929
gptkbp:bfsParent gptkb:11p15.5
gptkbp:bfsLayer 6