|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:AREG
gptkb:schwannoma-derived_growth_factor
SDGF
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
asthma
cell proliferation
colorectal cancer
pancreatic cancer
prostate cancer
wound healing
psoriasis
rheumatoid arthritis
inflammatory bowel disease
|
|
gptkbp:biologicalProcess
|
inflammatory response
growth factor activity
positive regulation of cell proliferation
epidermal growth factor receptor signaling pathway
|
|
gptkbp:discoveredBy
|
Shoyab et al.
|
|
gptkbp:encodes
|
gptkb:amphiregulin
|
|
gptkbp:Entrez_Gene_ID
|
374
ENSG00000109321
|
|
gptkbp:expressedIn
|
epithelial tissues
|
|
gptkbp:firstDescribed
|
1988
|
|
gptkbp:function
|
growth factor activity
EGFR ligand
|
|
gptkbp:GO_term
|
GO:0008083
GO:0007173
|
|
gptkbp:HGNC_ID
|
HGNC:651
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
AREG gene
|
|
gptkbp:length
|
252 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_4
4q13.3
|
|
gptkbp:OMIM
|
300206
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Areg
|
|
gptkbp:product
|
amphiregulin precursor
|
|
gptkbp:proteinFamily
|
gptkb:EGF_family
|
|
gptkbp:RefSeq
|
NM_001657
|
|
gptkbp:regulates
|
regulated by cytokines
regulated by EGF
regulated by TGF-alpha
upregulated by estrogen
|
|
gptkbp:UniProtID
|
P15514
|
|
gptkbp:bfsParent
|
gptkb:amphiregulin
|
|
gptkbp:bfsLayer
|
7
|