Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:affects |
lipid metabolism
|
| gptkbp:aminoAcidChange |
arginine at positions 112 and 158
|
| gptkbp:associatedWith |
gptkb:Alzheimer's_disease
gptkb:cardiovascular_disease |
| gptkbp:discoveredBy |
genetic studies
|
| gptkbp:frequency |
~15% worldwide
|
| https://www.w3.org/2000/01/rdf-schema#label |
APOE-e4
|
| gptkbp:locatedOnChromosome |
gptkb:chromosome_19
|
| gptkbp:riskFactor |
gptkb:Alzheimer's_disease
gptkb:Parkinson's_disease gptkb:late-onset_Alzheimer's_disease cognitive decline atherosclerosis cerebral amyloid angiopathy Lewy body dementia age-related macular degeneration frontotemporal dementia increased risk of institutionalization in Alzheimer's age-related cognitive decline increased amyloid plaque deposition increased blood-brain barrier breakdown increased neuroinflammation increased risk of agitation in Alzheimer's increased risk of caregiver burden in Alzheimer's increased risk of delusions in Alzheimer's increased risk of depression in Alzheimer's increased risk of epilepsy in Alzheimer's increased risk of falls in Alzheimer's increased risk of hallucinations in Alzheimer's increased risk of mortality in Alzheimer's increased risk of pneumonia in Alzheimer's increased risk of psychosis in Alzheimer's increased risk of seizures in Alzheimer's increased risk of wandering in Alzheimer's increased tau pathology multiple sclerosis progression poor recovery after brain injury poorer brain glucose metabolism poorer cognitive reserve poorer executive function poorer memory performance poorer outcome after stroke poorer outcome after traumatic brain injury poorer response to head injury poorer response to some Alzheimer's drugs poorer response to statins increased risk of sleep disturbances in Alzheimer's |
| gptkbp:variant |
gptkb:APOE
|
| gptkbp:bfsParent |
gptkb:APOE-e2
gptkb:APOE-e3 |
| gptkbp:bfsLayer |
6
|