Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alsoKnownAs |
gptkb:ATPases_Associated_with_diverse_cellular_Activities
|
| gptkbp:associatedWith |
gptkb:cancer
neurodegenerative diseases cardiomyopathy muscular dystrophy inherited ataxias |
| gptkbp:database |
InterPro: IPR003593
PROSITE: PS00674 Pfam: PF00004 SCOP: 1e32 |
| gptkbp:domain |
gptkb:AAA_domain
|
| gptkbp:evolvesFrom |
gptkb:P-loop_NTPase_superfamily
|
| gptkbp:firstDescribed |
1990s
|
| gptkbp:foundIn |
gptkb:Bacteria
archaea eukaryotes |
| gptkbp:function |
DNA replication
protein degradation protein unfolding membrane fusion protein disaggregation ATP hydrolysis |
| https://www.w3.org/2000/01/rdf-schema#label |
AAA+ ATPase proteins
|
| gptkbp:involvedIn |
DNA repair
cell cycle regulation mitochondrial function vesicle trafficking protein quality control cellular homeostasis cytoskeletal organization organelle biogenesis chromatin remodeling |
| gptkbp:motif |
gptkb:Walker_A_motif
gptkb:Walker_B_motif gptkb:arginine_finger |
| gptkbp:powerSource |
gptkb:ATP
|
| gptkbp:regulates |
histone modification
nucleotide binding cofactor interaction |
| gptkbp:structure |
hexameric ring
oligomeric complex |
| gptkbp:superfamily |
gptkb:NSF
gptkb:Clp_protease gptkb:dynein gptkb:p97/VCP gptkb:Hsp104 MCM helicase |
| gptkbp:bfsParent |
gptkb:AAA_domain
|
| gptkbp:bfsLayer |
7
|