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gptkbp:instanceOf
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gptkb:protein
|
|
gptkbp:alternativeName
|
RplB
ribosomal protein L2
|
|
gptkbp:antibioticTarget
|
not a primary target
|
|
gptkbp:component
|
50S ribosomal subunit
|
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gptkbp:conservedIn
|
gptkb:Bacteria
archaea
|
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gptkbp:encodedBy
|
rplB gene
|
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gptkbp:evolutionaryConservation
|
high
|
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gptkbp:firstDescribed
|
1960s
|
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gptkbp:foundIn
|
prokaryotes
|
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gptkbp:function
|
structural constituent of ribosome
peptidyltransferase activity
rRNA binding
|
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gptkbp:gene
|
gptkb:rplB
|
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gptkbp:GO_term
|
GO:0003735
GO:0005840
GO:0006412
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
50S ribosomal protein L2
|
|
gptkbp:interactsWith
|
gptkb:23S_rRNA
ribosomal protein L3
ribosomal protein L4
|
|
gptkbp:InterPro
|
IPR002671
|
|
gptkbp:length
|
273 amino acids (E. coli)
|
|
gptkbp:location
|
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
~29 kDa
|
|
gptkbp:mutationAssociatedWith
|
can cause antibiotic resistance
can impair ribosome function
|
|
gptkbp:orthologIn
|
chloroplasts
mitochondria
|
|
gptkbp:PDB
|
1VY4
2AW4
4V4Q
|
|
gptkbp:postTranslationalModification
|
methylation possible
|
|
gptkbp:presentIn
|
gptkb:Salmonella_enterica
gptkb:Mycobacterium_tuberculosis
gptkb:Staphylococcus_aureus
gptkb:Bacteria
gptkb:Bacillus_subtilis
|
|
gptkbp:proteinFamily
|
PF00181
|
|
gptkbp:requires
|
ribosome assembly
|
|
gptkbp:role
|
translator
peptide bond formation
ribosome stability
|
|
gptkbp:structure
|
alpha/beta
|
|
gptkbp:subunitContact
|
forms bridge to 30S subunit
|
|
gptkbp:taxonAuthor
|
gptkb:Bacteria
Archaea
|
|
gptkbp:UniProtID
|
P60422
|
|
gptkbp:bfsParent
|
gptkb:Ribosomal_Protein_B
|
|
gptkbp:bfsLayer
|
8
|