20S proteasome core complex

URI: https://gptkb.org/entity/20S_proteasome_core_complex
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeTo gptkb:immunoproteasome
gptkb:thymoproteasome
gptkbp:arrangedFor four stacked rings
gptkbp:component gptkb:26S_proteasome
gptkbp:composedOf beta subunits
alpha subunits
gptkbp:discoveredIn 1980s
gptkbp:EC_number 3.4.25.1
gptkbp:encodedBy PSMA genes
PSMB genes
gptkbp:foundIn archaea
eukaryotic cells
gptkbp:function protein degradation
proteolysis
gptkbp:GO_term GO:0000502
gptkbp:hasBiologicalActivity caspase-like
chymotrypsin-like
trypsin-like
https://www.w3.org/2000/01/rdf-schema#label 20S proteasome core complex
gptkbp:inhibitedBy gptkb:bortezomib
gptkb:lactacystin
MG132
gptkbp:involvedIn gptkb:ubiquitin-proteasome_pathway
protein quality control
antigen processing
gptkbp:location gptkb:nucleus
gptkb:cytoplasm
gptkbp:molecularWeight ~700 kDa
gptkbp:numberOfSubunits 28
gptkbp:PDB 1IRU
5LE5
gptkbp:regulates gptkb:19S_regulatory_particle
PA28 activator
gptkbp:requires apoptosis
signal transduction
cell cycle regulation
immune response
gptkbp:ringComposition two inner beta rings
two outer alpha rings
gptkbp:shape barrel-shaped
gptkbp:studiedBy X-ray crystallography
cryo-electron microscopy
gptkbp:substrate ubiquitinated proteins
oxidized proteins
gptkbp:UniProtID P25786
P28074
gptkbp:bfsParent gptkb:PSM2
gptkbp:bfsLayer 7