|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:15-LO
gptkb:arachidonate_15-lipoxygenase
LOX-15
|
|
gptkbp:catalyzes
|
oxygenation of polyunsaturated fatty acids
|
|
gptkbp:cofactor
|
iron
|
|
gptkbp:discoveredBy
|
gptkb:Olof_Hammarsten
|
|
gptkbp:discoveredIn
|
1975
|
|
gptkbp:EC_number
|
1.13.11.33
|
|
gptkbp:expressedIn
|
macrophages
epithelial cells
reticulocytes
|
|
gptkbp:foundIn
|
humans
mice
plants
|
|
gptkbp:fullName
|
gptkb:15-lipoxygenase
|
|
gptkbp:gene
|
gptkb:ALOX15
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
15-LOX
|
|
gptkbp:inhibitedBy
|
gptkb:baicalein
gptkb:nordihydroguaiaretic_acid_(NDGA)
|
|
gptkbp:involvedIn
|
cell differentiation
lipid metabolism
inflammation
|
|
gptkbp:locatedOnChromosome
|
gptkb:17p13.1_(human)
|
|
gptkbp:orthologIn
|
ALOX12
ALOX15B
|
|
gptkbp:pathway
|
eicosanoid biosynthesis
lipoxin biosynthesis
|
|
gptkbp:produces
|
13-hydroperoxyoctadecadienoic acid (13-HPODE)
15-hydroperoxyeicosatetraenoic acid (15-HPETE)
|
|
gptkbp:product
|
13-HODE
15-HETE
|
|
gptkbp:relatedTo
|
gptkb:cancer
asthma
atherosclerosis
|
|
gptkbp:structureType
|
non-heme iron-containing enzyme
|
|
gptkbp:substrate
|
gptkb:arachidonic_acid
gptkb:linoleic_acid
|
|
gptkbp:bfsParent
|
gptkb:15-lipoxygenase_protein
gptkb:ALOX15
gptkb:arachidonate_15-lipoxygenase
|
|
gptkbp:bfsLayer
|
7
|