|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:15-LOX
gptkb:LOX15
gptkb:ALOX15
|
|
gptkbp:associatedWith
|
asthma
atherosclerosis
|
|
gptkbp:biologicalProcess
|
cell differentiation
lipid metabolism
inflammatory response
|
|
gptkbp:cofactor
|
iron
|
|
gptkbp:encodedBy
|
gptkb:ALOX15_gene
|
|
gptkbp:enzymeCommissionNumber
|
gptkb:EC_1.13.11.33
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
catalyzes the dioxygenation of polyunsaturated fatty acids
|
|
gptkbp:inhibitedBy
|
gptkb:baicalein
gptkb:nordihydroguaiaretic_acid_(NDGA)
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_17p13.1
|
|
gptkbp:location
|
cytosol
|
|
gptkbp:molecularWeight
|
~75 kDa
|
|
gptkbp:orthologIn
|
gptkb:mouse_Alox15_protein
|
|
gptkbp:product
|
13-hydroperoxyoctadecadienoic acid (13-HPODE)
15-hydroperoxyeicosatetraenoic acid (15-HPETE)
|
|
gptkbp:structure
|
contains a PLAT domain
contains a lipoxygenase domain
|
|
gptkbp:substrate
|
gptkb:arachidonic_acid
gptkb:linoleic_acid
|
|
gptkbp:UniProtID
|
P16050
|
|
gptkbp:bfsParent
|
gptkb:AAH
|
|
gptkbp:bfsLayer
|
6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
15-lipoxygenase protein
|