Statements (62)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:physicist
|
| gptkbp:associated_with |
gptkb:asthma
gptkb:healthcare_organization gptkb:Crohn's_disease gptkb:systemic_lupus_erythematosus gptkb:ulcerative_colitis gptkb:Company gptkb:psychologist gptkb:rheumatoid_arthritis hypertension liver diseases metabolic syndrome cardiovascular diseases sepsis psoriasis atherosclerosis chronic inflammation kidney diseases pulmonary diseases chronic obstructive pulmonary disease gout ischemia-reperfusion injury hyperuricemia |
| gptkbp:clinical_trial |
treatment of gout
diagnostic marker for certain diseases |
| gptkbp:established |
gptkb:resveratrol
vitamin E curcumin quercetin reduces uric acid levels reduces oxidative stress probenecid allopurinol febuxostat sulfinpyrazone |
| gptkbp:function |
purine metabolism
|
| https://www.w3.org/2000/01/rdf-schema#label |
xanthine oxidase
|
| gptkbp:is_a_route_for |
oxidative phosphorylation
nucleotide metabolism purine catabolism reactive oxygen species generation xanthine degradation pathway |
| gptkbp:is_found_in |
human liver
human intestine |
| gptkbp:is_involved_in |
oxidative stress
|
| gptkbp:location |
mitochondria
cytosol |
| gptkbp:material |
gptkb:xanthine
hypoxanthine |
| gptkbp:produced_by |
reactive oxygen species
|
| gptkbp:products |
uric acid
superoxide anion |
| gptkbp:promoter |
XDH
|
| gptkbp:role |
cell signaling
immune response inflammation antioxidant defense purine degradation |
| gptkbp:was_a_catalyst_for |
oxidation of hypoxanthine to xanthine
oxidation of xanthine to uric acid |
| gptkbp:bfsParent |
gptkb:xanthine
|
| gptkbp:bfsLayer |
5
|