|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeTo
|
gptkb:xanthine_dehydrogenase
|
|
gptkbp:associatedWith
|
gptkb:xanthinuria
gout
|
|
gptkbp:catalyzes
|
oxidation of hypoxanthine to xanthine
oxidation of xanthine to uric acid
|
|
gptkbp:cofactor
|
gptkb:FAD
molybdenum
iron-sulfur cluster
|
|
gptkbp:converts_to
|
gptkb:xanthine_dehydrogenase
|
|
gptkbp:EC_number
|
1.17.3.2
|
|
gptkbp:expressedIn
|
endothelial cells
liver cells
|
|
gptkbp:foundIn
|
liver
intestine
|
|
gptkbp:gene
|
gptkb:XDH
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
xanthine oxidase
|
|
gptkbp:inhibitedBy
|
gptkb:captopril
allopurinol
quercetin
rutin
nicotinamide
apigenin
kaempferol
luteolin
febuxostat
BOF-4272
FYX-051
Y-700
ferricyanide
oxypurinol
pterin
tebuxostat
topiroxostat
|
|
gptkbp:involves
|
purine metabolism
|
|
gptkbp:molecularWeight
|
~290 kDa
|
|
gptkbp:PDB
|
1FIQ
|
|
gptkbp:presentIn
|
humans
many mammals
|
|
gptkbp:produces
|
reactive oxygen species
uric acid
|
|
gptkbp:product
|
hydrogen peroxide
uric acid
superoxide
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:substrate
|
gptkb:hypoxanthine
gptkb:xanthine
|
|
gptkbp:systematicName
|
xanthine:oxygen oxidoreductase
|
|
gptkbp:UniProtID
|
gptkb:P47989
|
|
gptkbp:bfsParent
|
gptkb:hypoxanthine
gptkb:xanthine
gptkb:Flavin_adenine_dinucleotide
gptkb:aldehyde_oxidase
|
|
gptkbp:bfsLayer
|
7
|