wild-type ATTR amyloidosis

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:disease
gptkbp:affects	gptkb:nervous_system gptkb:carpal_tunnel heart
gptkbp:alsoKnownAs	gptkb:senile_systemic_amyloidosis ATTRwt amyloidosis
gptkbp:category	gptkb:amyloidosis cardiac amyloidosis systemic amyloidosis
gptkbp:causedBy	deposition of wild-type transthyretin protein transthyretin gene mutation
gptkbp:commonIn	elderly men
gptkbp:complication	gptkb:arrhythmias congestive heart failure restrictive cardiomyopathy conduction system disease
gptkbp:depositsFoundIn	ligaments tendons myocardium peripheral nerves
gptkbp:diagnosedBy	mass spectrometry biopsy cardiac MRI technetium pyrophosphate scan
gptkbp:differentialDiagnosis	hereditary ATTR amyloidosis AL amyloidosis
gptkbp:firstDescribed	late 20th century
gptkbp:hasBiomarker	gptkb:troponin gptkb:NT-proBNP transthyretin levels
gptkbp:hasEpidemiology	most common form of cardiac amyloidosis in elderly
gptkbp:hasGeneticCause	none (wild-type, not mutated)
gptkbp:ICD-10_code	E85.1
gptkbp:involvesProtein	gptkb:transthyretin
gptkbp:prevalence	increases with age
gptkbp:prognosis	variable, often poor if advanced
gptkbp:riskFactor	male sex advanced age
gptkbp:symptom	gptkb:peripheral_neuropathy gptkb:arrhythmia gptkb:carpal_tunnel_syndrome heart failure
gptkbp:treatment	gptkb:patisiran gptkb:tafamidis supportive care diuretics heart failure medications
gptkbp:bfsParent	gptkb:ATTR_amyloidosis
gptkbp:bfsLayer	8
https://www.w3.org/2000/01/rdf-schema#label	wild-type ATTR amyloidosis