Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:disease
|
| gptkbp:affects |
gptkb:nervous_system
gptkb:carpal_tunnel heart |
| gptkbp:alsoKnownAs |
gptkb:senile_systemic_amyloidosis
ATTRwt amyloidosis |
| gptkbp:category |
amyloidosis
cardiac amyloidosis systemic amyloidosis |
| gptkbp:causedBy |
deposition of wild-type transthyretin protein
transthyretin gene mutation |
| gptkbp:commonIn |
elderly men
|
| gptkbp:complication |
gptkb:arrhythmias
congestive heart failure restrictive cardiomyopathy conduction system disease |
| gptkbp:depositsFoundIn |
ligaments
tendons myocardium peripheral nerves |
| gptkbp:diagnosedBy |
mass spectrometry
biopsy cardiac MRI technetium pyrophosphate scan |
| gptkbp:differentialDiagnosis |
hereditary ATTR amyloidosis
AL amyloidosis |
| gptkbp:firstDescribed |
late 20th century
|
| gptkbp:hasBiomarker |
gptkb:troponin
gptkb:NT-proBNP transthyretin levels |
| gptkbp:hasEpidemiology |
most common form of cardiac amyloidosis in elderly
|
| gptkbp:hasGeneticCause |
none (wild-type, not mutated)
|
| https://www.w3.org/2000/01/rdf-schema#label |
wild-type ATTR amyloidosis
|
| gptkbp:ICD-10_code |
E85.1
|
| gptkbp:involvesProtein |
gptkb:transthyretin
|
| gptkbp:prevalence |
increases with age
|
| gptkbp:prognosis |
variable, often poor if advanced
|
| gptkbp:riskFactor |
male sex
advanced age |
| gptkbp:symptom |
gptkb:arrhythmia
gptkb:carpal_tunnel_syndrome heart failure peripheral neuropathy |
| gptkbp:treatment |
gptkb:patisiran
gptkb:tafamidis supportive care diuretics heart failure medications |
| gptkbp:bfsParent |
gptkb:ATTR_amyloidosis
|
| gptkbp:bfsLayer |
8
|