|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeName
|
exrA
uvrA1
uvrA2
|
|
gptkbp:biologicalProcess
|
DNA damage recognition
DNA binding
ATPase activity
initiation of excision repair
recruitment of UvrB
|
|
gptkbp:discoveredBy
|
Setlow and Carrier
|
|
gptkbp:EC_number
|
3.6.4.12
|
|
gptkbp:encodes
|
gptkb:UvrA_protein
|
|
gptkbp:Entrez_Gene_ID
|
945006 (NCBI, E. coli)
|
|
gptkbp:expressedUnder
|
gptkb:SOS_response
|
|
gptkbp:firstDescribed
|
1964
|
|
gptkbp:formsComplexWith
|
gptkb:UvrB_protein
gptkb:UvrC_protein
|
|
gptkbp:foundIn
|
gptkb:Bacteria
|
|
gptkbp:hasEnsemblBacteriaID
|
EBI-EBI-1000001
|
|
gptkbp:hasGOAnnotation
|
GO:0003677 (DNA binding)
GO:0005524 (ATP binding)
GO:0006289 (nucleotide-excision repair)
|
|
gptkbp:hasOperon
|
uvrA-uvrB operon (in some bacteria)
|
|
gptkbp:hasPromoter
|
upstream of coding region
|
|
gptkbp:hasRefSeqID
|
NP_415299.1 (E. coli)
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
uvrA gene
|
|
gptkbp:involvedIn
|
nucleotide excision repair
|
|
gptkbp:KEGGID
|
eco:b0778
|
|
gptkbp:length
|
2931 bp (E. coli)
940 amino acids (E. coli)
|
|
gptkbp:locatedOn
|
gptkb:E._coli_chromosome
|
|
gptkbp:locusTag
|
b0778 (E. coli K-12)
|
|
gptkbp:mutationAssociatedWith
|
defective DNA repair
UV sensitivity
|
|
gptkbp:orthologIn
|
gptkb:Pseudomonas_aeruginosa
gptkb:Mycobacterium_tuberculosis
gptkb:Bacillus_subtilis
human ERCC6L2
yeast RAD3
|
|
gptkbp:participatedIn
|
DNA repair
|
|
gptkbp:PDB
|
2R6F (UvrA protein, E. coli)
|
|
gptkbp:product
|
ATP-dependent DNA repair enzyme UvrA
|
|
gptkbp:proteinFamily
|
ABC transporter-like ATPase
|
|
gptkbp:regulates
|
gptkb:LexA_protein
UvrA protein expression
|
|
gptkbp:requires
|
removal of bulky DNA lesions
UV resistance
|
|
gptkbp:transcriptionDirection
|
forward (E. coli)
|
|
gptkbp:UniProtID
|
P03018 (UvrA protein, E. coli)
|
|
gptkbp:bfsParent
|
gptkb:SOS_protein
|
|
gptkbp:bfsLayer
|
7
|