|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:dystrophin-related_protein
|
|
gptkbp:discoveredBy
|
Khurana et al.
|
|
gptkbp:discoveredIn
|
1989
|
|
gptkbp:downregulatedIn
|
adult muscle
|
|
gptkbp:encodedBy
|
gptkb:UTRN_gene
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:adrenal_gland
gptkb:kidney
gptkb:placenta
gptkb:prostate
gptkb:testis
gptkb:thymus
brain
heart
gastrointestinal tract
retina
liver
spleen
bladder
pancreas
fetal development
Schwann cells
endothelial cells
smooth muscle
|
|
gptkbp:foundIn
|
humans
other mammals
|
|
gptkbp:function
|
cytoskeletal protein
links cytoskeleton to extracellular matrix
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
utrophin
|
|
gptkbp:interactsWith
|
gptkb:dystrobrevin
gptkb:dystroglycan_complex
gptkb:syntrophins
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_6q24
|
|
gptkbp:location
|
gptkb:sarcolemma
neuromuscular junction
fetal muscle
|
|
gptkbp:molecularWeight
|
395 kDa
|
|
gptkbp:OMIM
|
128240
|
|
gptkbp:potentialTherapyFor
|
gptkb:Duchenne_muscular_dystrophy
|
|
gptkbp:role
|
gptkb:Duchenne_muscular_dystrophy
|
|
gptkbp:similarTo
|
gptkb:dystrophin
|
|
gptkbp:structure
|
contains C-terminal domain
contains cysteine-rich domain
contains actin-binding domain
contains spectrin-like repeats
|
|
gptkbp:UniProtID
|
P46939
|
|
gptkbp:upregulatedBy
|
muscle regeneration
|
|
gptkbp:bfsParent
|
gptkb:dystrophin_family
|
|
gptkbp:bfsLayer
|
6
|