triose phosphate isomerase

URI: https://gptkb.org/entity/triose_phosphate_isomerase
GPTKB entity
Statements (31)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:activeSiteResidue Glu165
His95
gptkbp:alternativeName gptkb:TPI
gptkb:TIM
gptkbp:associatedWith gptkb:anemia
gptkbp:biologicalProcess isomerase activity
gptkbp:catalyzes interconversion of dihydroxyacetone phosphate and glyceraldehyde 3-phosphate
gptkbp:cofactor none
gptkbp:deficiencyCauses gptkb:triosephosphate_isomerase_deficiency
gptkbp:discoveredBy 1930s
gptkbp:EC_number 5.3.1.1
gptkbp:enzyme_commission_class gptkb:isomerase
gptkbp:enzyme_mechanism proceeds via enediol intermediate
gptkbp:first_structure_solved 1975
gptkbp:foldable gptkb:TIM_barrel
gptkbp:foundIn gptkb:gluconeogenesis_pathway
gptkb:glycolysis_pathway
gptkbp:gene gptkb:TPI1
gptkbp:gene_location_(human) gptkb:chromosome_12p13
https://www.w3.org/2000/01/rdf-schema#label triose phosphate isomerase
gptkbp:inhibitedBy phosphoglycolohydroxamate
gptkbp:molecularWeight 27 kDa
gptkbp:organism present in all domains of life
gptkbp:PDB gptkb:1TIM
gptkbp:requires energy metabolism
gptkbp:structure homodimer
gptkbp:subcellularLocation gptkb:cytoplasm
gptkbp:UniProtID gptkb:P60174
gptkbp:bfsParent gptkb:Calvin_cycle
gptkbp:bfsLayer 6