gptkbp:instanceOf
|
gptkb:drug
antidepressant
serotonin antagonist and reuptake inhibitor
|
gptkbp:approvalYear
|
1970s
|
gptkbp:approvedBy
|
gptkb:Italy
|
gptkbp:ATCCode
|
N06AX05
|
gptkbp:availableOn
|
gptkb:tablet
extended-release tablet
|
gptkbp:brand
|
gptkb:Desyrel
gptkb:Oleptro
gptkb:Trittico
|
gptkbp:CASNumber
|
19794-93-5
|
gptkbp:chemicalFormula
|
C19H22ClN5O
|
gptkbp:contraindication
|
recent myocardial infarction
hypersensitivity to trazodone
|
gptkbp:developedBy
|
gptkb:Italy
|
gptkbp:discoveredBy
|
Angelini Group
|
gptkbp:discoveredIn
|
1966
|
gptkbp:eliminationHalfLife
|
5-13 hours
|
gptkbp:excretion
|
kidneys
|
https://www.w3.org/2000/01/rdf-schema#label
|
trazodone
|
gptkbp:interactsWith
|
gptkb:beer
gptkb:MAO_inhibitors
gptkb:CNS_depressants
other serotonergic drugs
|
gptkbp:legalStatus
|
prescription only
|
gptkbp:mechanismOfAction
|
serotonin reuptake inhibition
5-HT2A receptor antagonism
alpha-1 adrenergic receptor antagonism
histamine H1 receptor antagonism
|
gptkbp:metabolism
|
gptkb:m-chlorophenylpiperazine_(mCPP)
liver
|
gptkbp:notRecommendedFor
|
children
|
gptkbp:pregnancyCategory
|
C (US)
|
gptkbp:prescribes
|
adults
elderly
|
gptkbp:riskFactor
|
gptkb:serotonin_syndrome
QT prolongation
suicidal thoughts (in young people)
|
gptkbp:routeOfAdministration
|
oral
|
gptkbp:sideEffect
|
gptkb:orthostatic_hypotension
nausea
dizziness
headache
drowsiness
dry mouth
priapism
|
gptkbp:usedFor
|
gptkb:major_depressive_disorder
insomnia
anxiety disorders
off-label uses
|
gptkbp:bfsParent
|
gptkb:Buspirone
gptkb:5-HT2C_receptor
|
gptkbp:bfsLayer
|
7
|