trazodone

GPTKB entity

Statements (54)
Predicate Object
gptkbp:instanceOf gptkb:drug
antidepressant
serotonin antagonist and reuptake inhibitor
gptkbp:approvalYear 1970s
gptkbp:approvedBy gptkb:Italy
gptkbp:ATCCode N06AX05
gptkbp:availableOn gptkb:tablet
extended-release tablet
gptkbp:brand gptkb:Desyrel
gptkb:Oleptro
gptkb:Trittico
gptkbp:CASNumber 19794-93-5
gptkbp:chemicalFormula C19H22ClN5O
gptkbp:contraindication recent myocardial infarction
hypersensitivity to trazodone
gptkbp:developedBy gptkb:Italy
gptkbp:discoveredBy Angelini Group
gptkbp:discoveredIn 1966
gptkbp:eliminationHalfLife 5-13 hours
gptkbp:excretion kidneys
https://www.w3.org/2000/01/rdf-schema#label trazodone
gptkbp:interactsWith gptkb:beer
gptkb:MAO_inhibitors
gptkb:CNS_depressants
other serotonergic drugs
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction serotonin reuptake inhibition
5-HT2A receptor antagonism
alpha-1 adrenergic receptor antagonism
histamine H1 receptor antagonism
gptkbp:metabolism gptkb:m-chlorophenylpiperazine_(mCPP)
liver
gptkbp:notRecommendedFor children
gptkbp:pregnancyCategory C (US)
gptkbp:prescribes adults
elderly
gptkbp:riskFactor gptkb:serotonin_syndrome
QT prolongation
suicidal thoughts (in young people)
gptkbp:routeOfAdministration oral
gptkbp:sideEffect gptkb:orthostatic_hypotension
nausea
dizziness
headache
drowsiness
dry mouth
priapism
gptkbp:usedFor gptkb:major_depressive_disorder
insomnia
anxiety disorders
off-label uses
gptkbp:bfsParent gptkb:Buspirone
gptkb:5-HT2C_receptor
gptkbp:bfsLayer 7