toxic epidermal necrolysis

URI: https://gptkb.org/entity/toxic_epidermal_necrolysis
GPTKB entity
Statements (44)
Predicate Object
gptkbp:instanceOf gptkb:disease
skin disorder
gptkbp:affects gptkb:skin
mucous membranes
gptkbp:age all ages
gptkbp:alsoKnownAs TEN
gptkbp:causedBy infection
adverse drug reaction
gptkbp:characterizedBy mucous membrane involvement
widespread skin detachment
gptkbp:commonHealthIssues gptkb:NSAIDs
allopurinol
anticonvulsants
sulfonamides
gptkbp:complication sepsis
multi-organ failure
gptkbp:diagnosedBy clinical examination
skin biopsy
gptkbp:differentialDiagnosis gptkb:pemphigus_vulgaris
gptkb:erythema_multiforme
gptkb:staphylococcal_scalded_skin_syndrome
gptkbp:firstDescribed 1956
gptkbp:hasEpidemiology rare
https://www.w3.org/2000/01/rdf-schema#label toxic epidermal necrolysis
gptkbp:ICD-10_code L51.2
gptkbp:mortalityRate high
gptkbp:pathology keratinocyte apoptosis
gptkbp:percentageBodySurfaceArea >30%
gptkbp:prognosis poor
gptkbp:relatedTo gptkb:Stevens-Johnson_syndrome
gptkbp:riskFactor immunosuppression
HIV infection
gptkbp:sex both sexes
gptkbp:symptom fever
conjunctivitis
blistering
skin pain
gptkbp:treatment gptkb:cyclosporine
supportive care
corticosteroids
IV immunoglobulin
gptkbp:bfsParent gptkb:Stevens–Johnson_syndrome
gptkb:phenytoin
gptkbp:bfsLayer 6