|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:AComponentFunction
|
enzymatic activity
|
|
gptkbp:affects
|
gptkb:nervous_system
|
|
gptkbp:alsoKnownAs
|
gptkb:tetanospasmin
|
|
gptkbp:antigen
|
yes
|
|
gptkbp:BComponentFunction
|
binding to neurons
|
|
gptkbp:category
|
gptkb:Dragon
gptkb:bacterial_toxin
|
|
gptkbp:cause
|
tetanus
|
|
gptkbp:discoveredBy
|
gptkb:Kitasato_ShibasaburÅ
gptkb:Emil_von_Behring
|
|
gptkbp:encodedBy
|
tetX gene
|
|
gptkbp:firstDescribed
|
1890
|
|
gptkbp:inhibitedBy
|
release of GABA
release of glycine
|
|
gptkbp:LD50
|
~2.5 ng/kg (human, estimated)
|
|
gptkbp:mechanismOfAction
|
inhibits neurotransmitter release
|
|
gptkbp:molecularWeight
|
150 kDa
|
|
gptkbp:neutralizedBy
|
tetanus antitoxin
|
|
gptkbp:producedBy
|
gptkb:Clostridium_tetani
|
|
gptkbp:structure
|
A-B toxin
|
|
gptkbp:target
|
motor neurons
|
|
gptkbp:toxicity
|
highly potent
|
|
gptkbp:transportation
|
retrograde axonal transport
|
|
gptkbp:usedIn
|
tetanus toxoid vaccine
|
|
gptkbp:bfsParent
|
gptkb:Vesicle-associated_membrane_protein
gptkb:tetanospasmin
gptkb:SNARE_proteins
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
tetanus toxin
|