Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:AComponentFunction |
enzymatic activity
|
| gptkbp:affects |
gptkb:nervous_system
|
| gptkbp:alsoKnownAs |
gptkb:tetanospasmin
|
| gptkbp:antigen |
yes
|
| gptkbp:BComponentFunction |
binding to neurons
|
| gptkbp:category |
gptkb:Dragon
bacterial toxin |
| gptkbp:cause |
tetanus
|
| gptkbp:discoveredBy |
gptkb:Kitasato_ShibasaburÅ
gptkb:Emil_von_Behring |
| gptkbp:encodedBy |
tetX gene
|
| gptkbp:firstDescribed |
1890
|
| https://www.w3.org/2000/01/rdf-schema#label |
tetanus toxin
|
| gptkbp:inhibitedBy |
release of GABA
release of glycine |
| gptkbp:LD50 |
~2.5 ng/kg (human, estimated)
|
| gptkbp:mechanismOfAction |
inhibits neurotransmitter release
|
| gptkbp:molecularWeight |
150 kDa
|
| gptkbp:neutralizedBy |
tetanus antitoxin
|
| gptkbp:producedBy |
gptkb:Clostridium_tetani
|
| gptkbp:structure |
A-B toxin
|
| gptkbp:target |
motor neurons
|
| gptkbp:toxicity |
highly potent
|
| gptkbp:transportation |
retrograde axonal transport
|
| gptkbp:usedIn |
tetanus toxoid vaccine
|
| gptkbp:bfsParent |
gptkb:exotoxin
|
| gptkbp:bfsLayer |
5
|