ten-eleven translocation methylcytosine dioxygenase 2
GPTKB entity
Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:application |
epigenetics studies
|
| gptkbp:associated_with |
gptkb:Oncology
gptkb:neurodegenerative_diseases aging chromatin remodeling metabolic disorders signal transduction transcription factors autoimmune diseases inflammation stem cell biology cardiovascular diseases cell signaling pathways tumorigenesis immunology tumor microenvironment cellular differentiation biological pathways epigenetic modifications RNA processing metastasis therapeutic targets solid tumors cellular reprogramming cancer stem cells therapeutic resistance cellular stress responses DNA methylation dynamics |
| gptkbp:catalytic_activity |
conversion of 5-methylcytosine to 5-hydroxymethylcytosine
|
| gptkbp:clinical_trial |
biomarker for cancer
|
| gptkbp:function |
demethylation of 5-methylcytosine
|
| gptkbp:fuselage_material |
5-methylcytosine
|
| gptkbp:genetic_studies |
myeloid malignancies
|
| https://www.w3.org/2000/01/rdf-schema#label |
ten-eleven translocation methylcytosine dioxygenase 2
|
| gptkbp:initiated_by |
small molecules
|
| gptkbp:interacts_with |
TET1
TET3 |
| gptkbp:involved_in |
DNA repair
cell cycle regulation developmental processes |
| gptkbp:is_expressed_in |
hematopoietic cells
|
| gptkbp:location |
gptkb:Atom
|
| gptkbp:orthologs |
TET2 in other species
|
| gptkbp:pathway |
epigenetic regulation
|
| gptkbp:product |
5-hydroxymethylcytosine
|
| gptkbp:promoter |
gptkb:TET2
|
| gptkbp:role |
cell differentiation
gene expression regulation |
| gptkbp:bfsParent |
gptkb:TET2
|
| gptkbp:bfsLayer |
6
|