Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:chemical_compound
natural product |
| gptkbp:ATCCode |
L01CD01
|
| gptkbp:CASNumber |
33069-62-4
|
| gptkbp:discoveredBy |
gptkb:Mansukh_C._Wani
gptkb:Monroe_E._Wall 1967 |
| gptkbp:hasBiologicalActivity |
anticancer agent
|
| gptkbp:hasInChIKey |
YSAUAVLOXLNGBK-UHFFFAOYSA-N
|
| gptkbp:hasMolecularFormula |
C47H51NO14
|
| gptkbp:hasSMILES |
CC1=C2C(=CC(=C1)OC)C(=O)OC2
|
| gptkbp:heldBy |
antineoplastic agent
metabolite mitotic inhibitor taxane diterpenoid plant alkaloid |
| https://www.w3.org/2000/01/rdf-schema#label |
taxol molecule
|
| gptkbp:isolated_from |
gptkb:Pacific_yew_tree
|
| gptkbp:IUPACName |
(2aR,4S,4aS,6R,9S,11S,12aR,12bS)-11-acetoxy-12b-benzoyloxy-9,12a-dihydroxy-4,6,8,8,12b-pentamethyl-10-oxo-2,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-7,11-methanocyclodeca[3,4]benz[1,2-b]oxet-6-yl benzoate
|
| gptkbp:listedOn |
gptkb:World_Health_Organization's_List_of_Essential_Medicines
|
| gptkbp:mass |
853.9 g/mol
|
| gptkbp:mechanismOfAction |
stabilizes microtubules
|
| gptkbp:meltingPoint |
216-217 °C
|
| gptkbp:otherName |
paclitaxel
|
| gptkbp:PubChem_CID |
36314
33419 |
| gptkbp:routeOfAdministration |
intravenous
|
| gptkbp:sideEffect |
gptkb:anemia
fever nausea vomiting diarrhea fatigue joint pain muscle pain hair loss peripheral neuropathy infections allergic reaction rash neutropenia thrombocytopenia liver toxicity bradycardia low blood pressure hypersensitivity reaction mouth sores |
| gptkbp:usedFor |
gptkb:cancer
|
| gptkbp:bfsParent |
gptkb:E_ring
gptkb:E_Ring |
| gptkbp:bfsLayer |
7
|