Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
chromosomal band
|
| gptkbp:alsoKnownAs |
gptkb:translocation_(1;19)(q23;p13)
|
| gptkbp:associatedWith |
pre-B cell phenotype
|
| gptkbp:breakpoint_on_chromosome_1 |
q23
|
| gptkbp:breakpoint_on_chromosome_19 |
p13
|
| gptkbp:chromosomes_involved |
gptkb:chromosome_19
chromosome 1 |
| gptkbp:commonIn |
leukemia
|
| gptkbp:detects |
gptkb:FISH
karyotyping |
| gptkbp:firstDescribed |
1980s
|
| gptkbp:frequency |
5-6% of childhood pre-B ALL
|
| gptkbp:fusion_gene_product |
gptkb:E2A-PBX1
|
| gptkbp:gene_on_chromosome_1 |
gptkb:TCF3_(E2A)
|
| gptkbp:gene_on_chromosome_19 |
gptkb:PBX1
|
| https://www.w3.org/2000/01/rdf-schema#label |
t(1;19) translocation
|
| gptkbp:results_in_fusion_gene |
gptkb:TCF3-PBX1
|
| gptkbp:seen_in |
adult leukemia
pediatric leukemia |
| gptkbp:significance |
prognostic marker in ALL
|
| gptkbp:therapy_response |
variable prognosis
|
| gptkbp:bfsParent |
gptkb:Transcription_factor_E2-alpha
|
| gptkbp:bfsLayer |
6
|