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gptkbp:instanceOf
|
gptkb:disease
neurodegenerative disease
prion disease
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|
gptkbp:affects
|
central nervous system
|
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gptkbp:causedBy
|
misfolded prion protein
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gptkbp:diagnosedBy
|
gptkb:EEG
MRI
CSF 14-3-3 protein
definitive diagnosis by brain biopsy or autopsy
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gptkbp:distinctFrom
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gptkb:familial_CJD
gptkb:iatrogenic_CJD
gptkb:variant_CJD
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gptkbp:duration
|
months
|
|
gptkbp:firstDescribed
|
1920s
|
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gptkbp:hasNoCure
|
true
|
|
gptkbp:hasNoKnownCause
|
true
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
sporadic CJD
|
|
gptkbp:ICD-10_code
|
A81.0
|
|
gptkbp:incidence
|
1-2 cases per million per year
|
|
gptkbp:isMostCommonFormOf
|
gptkb:Creutzfeldt-Jakob_disease
|
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gptkbp:isNotTransmissibleBy
|
casual contact
|
|
gptkbp:mortalityRate
|
~100%
|
|
gptkbp:namedAfter
|
gptkb:Jakob
gptkb:Creutzfeldt
|
|
gptkbp:onset
|
typically age 60 or older
|
|
gptkbp:pathology
|
spongiform changes in brain tissue
|
|
gptkbp:prognosis
|
fatal
|
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gptkbp:riskFactor
|
older age
PRNP gene polymorphism
|
|
gptkbp:symptom
|
gptkb:dementia
behavioral changes
ataxia
myoclonus
visual disturbances
rapidly progressive cognitive decline
|
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gptkbp:treatment
|
supportive care
|
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gptkbp:bfsParent
|
gptkb:Creutzfeldt–Jakob_disease
|
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gptkbp:bfsLayer
|
6
|