Statements (81)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:Genetics
|
| gptkbp:affects |
males
|
| gptkbp:associated_with |
gptkb:depression
anxiety low self-esteem learning disabilities learning difficulties social difficulties increased risk of diabetes increased risk of metabolic syndrome infertility issues hypogonadism gynecomastia increased risk of certain cancers delayed puberty increased risk of autoimmune diseases increased risk of metabolic disorders increased risk of psychiatric disorders increased risk of dental problems increased risk of sleep apnea increased risk of kidney disease increased risk of liver disease increased risk of neurological disorders increased risk of osteoporosis increased risk of cardiovascular diseases increased risk of gastrointestinal disorders increased risk of hearing problems increased risk of respiratory disorders increased risk of skin disorders increased risk of thyroid disorders increased risk of vision problems |
| gptkbp:can_lead_to |
gptkb:Oncology
metabolic syndrome osteoporosis type 2 diabetes autoimmune disorders |
| gptkbp:caused_by |
extra X chromosome
|
| gptkbp:complications |
gptkb:chronic_fatigue_syndrome
gptkb:Oncology metabolic syndrome thromboembolic events heart disease osteoporosis type 2 diabetes autoimmune disorders germ cell tumors |
| gptkbp:diagnosis |
chromosomal analysis
karyotype analysis |
| gptkbp:discovered_by |
gptkb:1942
|
| gptkbp:first_described_by |
gptkb:Harry_Klinefelter
|
| gptkbp:genetic_studies |
nondisjunction
chorionic villus sampling amniocentesis recommended for symptomatic individuals |
| https://www.w3.org/2000/01/rdf-schema#label |
Klinefelter syndrome
|
| gptkbp:is_a_basis_for |
47, XXY karyotype
|
| gptkbp:is_involved_in |
available for affected individuals
|
| gptkbp:known_as |
47, XXY syndrome
|
| gptkbp:lifespan |
normal with treatment
|
| gptkbp:prevalence |
1 in 500 to 1 in 1,000 males
|
| gptkbp:research_focus |
genetic counseling
psychosocial support developing new therapies improving diagnosis understanding long-term outcomes |
| gptkbp:risk_factor |
family history
advanced maternal age |
| gptkbp:screenings |
not routinely screened
|
| gptkbp:symptoms |
infertility
tall stature breast tissue development reduced testosterone levels |
| gptkbp:treatment |
educational support
speech therapy psychological support testosterone therapy fertility treatment testosterone replacement therapy |
| gptkbp:bfsParent |
gptkb:Oncology
gptkb:Konoha |
| gptkbp:bfsLayer |
4
|