recombinant human alpha-L-iduronidase

URI: https://gptkb.org/entity/recombinant_human_alpha-L-iduronidase
GPTKB entity
Statements (41)
Predicate Object
gptkbp:instanceOf gptkb:biotechnology
gptkb:enzyme
gptkbp:administeredBy intravenous infusion
gptkbp:alternativeName gptkb:laronidase
gptkbp:approvedBy gptkb:FDA
gptkb:EMA
2003
gptkbp:ATCCode A16AB05
gptkbp:brand gptkb:Aldurazyme
gptkbp:CASNumber 37288-54-3
gptkbp:category orphan drug
gptkbp:geneTargeted gptkb:IDUA
https://www.w3.org/2000/01/rdf-schema#label recombinant human alpha-L-iduronidase
gptkbp:indication gptkb:Hurler-Scheie_syndrome
gptkb:Hurler_syndrome
gptkb:Scheie_syndrome
gptkbp:macromoleculeType gptkb:protein
gptkbp:mechanismOfAction replaces deficient alpha-L-iduronidase enzyme
gptkbp:producedBy gptkb:BioMarin_Pharmaceutical
gptkb:Genzyme
gptkbp:routeOfAdministration intravenous
gptkbp:sideEffect fever
nausea
vomiting
abdominal pain
headache
hypertension
pruritus
chest pain
rash
hypotension
allergic reactions
urticaria
infusion-related reactions
gptkbp:storage refrigerated
gptkbp:target alpha-L-iduronidase deficiency
gptkbp:UNII Q1L0WRS2Z2
gptkbp:usedFor enzyme replacement therapy
treatment of mucopolysaccharidosis I
gptkbp:bfsParent gptkb:Aldurazyme
gptkbp:bfsLayer 7