|
gptkbp:instanceOf
|
eicosanoid
prostaglandin
|
|
gptkbp:ATCCode
|
G04BE01
|
|
gptkbp:CASNumber
|
745-65-3
|
|
gptkbp:category
|
gptkb:drug
prostaglandin analog
vasodilator
|
|
gptkbp:chemicalFormula
|
C20H34O5
|
|
gptkbp:discoveredBy
|
gptkb:Ulf_von_Euler
|
|
gptkbp:discoveredIn
|
1935
|
|
gptkbp:excretion
|
urine
|
|
gptkbp:foundIn
|
human body
|
|
gptkbp:halfLife
|
5-10 minutes
|
|
gptkbp:hasProstanoidReceptor
|
gptkb:EP1
gptkb:EP2
gptkb:EP3
EP4
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
prostaglandin E1
|
|
gptkbp:IUPACName
|
(5Z,9α,11α,13E,15S)-11,15-dihydroxy-9,15-dimethylprosta-5,13-dien-1-oic acid
|
|
gptkbp:KEGGID
|
D00094
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:mechanismOfAction
|
vasodilation
inhibition of platelet aggregation
|
|
gptkbp:MeSH_ID
|
D011374
|
|
gptkbp:metabolism
|
gptkb:cancer
liver
|
|
gptkbp:molecularWeight
|
354.5 g/mol
|
|
gptkbp:origin
|
derived from arachidonic acid
|
|
gptkbp:otherName
|
alprostadil
|
|
gptkbp:pregnancyCategory
|
C (US)
|
|
gptkbp:producedBy
|
mammalian tissues
|
|
gptkbp:PubChem_CID
|
CHEMBL1201201
5280723
DB00770
|
|
gptkbp:relatedTo
|
prostaglandin E2
prostaglandin F2α
|
|
gptkbp:routeOfAdministration
|
intravenous
intracavernosal injection
urethral suppository
|
|
gptkbp:sideEffect
|
hypotension
flushing
priapism
penile pain
|
|
gptkbp:solubility
|
slightly soluble in water
|
|
gptkbp:UNII
|
Y45QSO73OB
|
|
gptkbp:usedFor
|
gptkb:patent_ductus_arteriosus
erectile dysfunction
peripheral vascular disease
|
|
gptkbp:bfsParent
|
gptkb:Transposition_of_the_great_arteries
|
|
gptkbp:bfsLayer
|
7
|