Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alternativeName |
gptkb:MDR1
Pgh1 |
| gptkbp:amplificationAssociatedWith |
mefloquine resistance
lumefantrine resistance |
| gptkbp:associatedWith |
antimalarial drug resistance
|
| gptkbp:encodes |
P-glycoprotein homolog
|
| gptkbp:Entrez_Gene_ID |
PF3D7_0523000
|
| gptkbp:fullName |
Plasmodium falciparum multidrug resistance protein 1
|
| gptkbp:function |
transmembrane transporter
|
| gptkbp:geneType |
ABC transporter
|
| https://www.w3.org/2000/01/rdf-schema#label |
pfmdr1
|
| gptkbp:length |
1419 amino acids
|
| gptkbp:locatedOnChromosome |
gptkb:chromosome_5
|
| gptkbp:mutationAssociatedWith |
D1246Y
N1042D N86Y S1034C Y184F alters sensitivity to artemisinin alters sensitivity to chloroquine alters sensitivity to lumefantrine alters sensitivity to mefloquine alters sensitivity to quinine |
| gptkbp:organism |
gptkb:Plasmodium_falciparum
|
| gptkbp:orthologIn |
gptkb:Plasmodium_knowlesi
gptkb:Plasmodium_vivax Plasmodium yoelii |
| gptkbp:relatedTo |
malaria treatment efficacy
|
| gptkbp:subcellularLocation |
digestive vacuole membrane
|
| gptkbp:bfsParent |
gptkb:Plasmodium_falciparum
|
| gptkbp:bfsLayer |
5
|