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gptkbp:instanceOf
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gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:MDR1
Pgh1
|
|
gptkbp:amplificationAssociatedWith
|
mefloquine resistance
lumefantrine resistance
|
|
gptkbp:associatedWith
|
antimalarial drug resistance
|
|
gptkbp:encodes
|
P-glycoprotein homolog
|
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gptkbp:Entrez_Gene_ID
|
PF3D7_0523000
|
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gptkbp:fullName
|
Plasmodium falciparum multidrug resistance protein 1
|
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gptkbp:function
|
gptkb:transmembrane_transporter
|
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gptkbp:geneType
|
gptkb:ABC_transporter
|
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gptkbp:length
|
1419 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_5
|
|
gptkbp:mutationAssociatedWith
|
D1246Y
N1042D
N86Y
S1034C
Y184F
alters sensitivity to artemisinin
alters sensitivity to chloroquine
alters sensitivity to lumefantrine
alters sensitivity to mefloquine
alters sensitivity to quinine
|
|
gptkbp:organism
|
gptkb:Plasmodium_falciparum
|
|
gptkbp:orthologIn
|
gptkb:Plasmodium_knowlesi
gptkb:Plasmodium_vivax
Plasmodium yoelii
|
|
gptkbp:relatedTo
|
malaria treatment efficacy
|
|
gptkbp:subcellularLocation
|
digestive vacuole membrane
|
|
gptkbp:bfsParent
|
gptkb:Plasmodium_falciparum
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
pfmdr1
|